Overview

  • Product name

    PACOCF3, phospholipase A2 inhibitor
  • Description

    Selective phospholipase A2 inhibitor
  • Biological description

    Selective phospholipase A2 inhibitor (IC50 = 3.8 μM). Four times more potent than arachidonyl trifluoromethyl ketone (ab120350). Alters Ca2+ signaling and impairs memory acquisition and retrieval. Active in vitro. Centrally active in vivo.
  • Purity

    > 98%
  • CAS Number

    141022-99-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Schaeffer EL & Gattaz WF Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats. J Neural Transm 114:379-85 (2007). Read more (PubMed: 17066253) »
  • Jan CR  et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol 74:447-51 (2000). Read more (PubMed: 11097381) »
  • Farooqui AA  et al. Inhibitors of intracellular phospholipase A2 activity: their neurochemical effects and therapeutical importance for neurological disorders. Brain Res Bull 49:139-53 (1999). Read more (PubMed: 10435777) »

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