PAK1 interacting protein 1 (PAK1IP1) negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N terminal regulatory domain. PAK1IP1 also binds to the N terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.
p21 activated protein kinase interacting protein 1 antibody
PAK- AND PLC-INTERACTING PROTEIN 1 antibody
PAK/PLC interacting protein 1 antibody
PAK1 interacting protein antibody
PIP 1 antibody
Putative PAK inhibitor Skb15 antibody
RP11 421M1.5 antibody
WD repeat containing protein 84 antibody
WDR 84 antibody
Immunoprecipitation - Anti-PAK1 interacting protein 1 antibody (ab176813)
Detection of PAK1 interacting protein 1 by Western Blot of Immunprecipitate. ab176813 at 1µg/ml labeling PAK1 interacting protein 1 in HeLa whole cell lysate immunoprecipitated using ab176813 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.
Western blot - Anti-PAK1 interacting protein 1 antibody (ab176813)
All lanes : Anti-PAK1 interacting protein 1 antibody (ab176813) at 0.04 µg/ml
Lane 1 : HeLa whole cell lysates at 50 µg Lane 2 : HeLa whole cell lysates at 15 µg Lane 3 : HeLa whole cell lysates at 5 µg Lane 4 : 293T whole cell lysates at 50 µg