Overview

  • Product name

    Anti-PAK1 + PAK2 + PAK3 antibody
    See all PAK1 + PAK2 + PAK3 primary antibodies
  • Description

    Rabbit polyclonal to PAK1 + PAK2 + PAK3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human PAK1 + PAK2 + PAK3. (Synthesized non-phosphopeptide derived from Human PAK1 + PAK2 + PAK3 around the phosphorylation site of threonine 423/402/421 (R-S-T(p)-M-V). [UniProt Q13153, O75914 andQ13177]).

  • Positive control

    • Human brain tissue; NIH/3T3 and 293 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab196834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
WB 1/500 - 1/3000. Predicted molecular weight: 61, 58, 62 kDa.

Target

  • Relevance

    In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death.
  • Cellular localization

    Cytoplasm. Recruited to focal adhesions upon activation
  • Database links

  • Alternative names

    • Alpha PAK antibody
    • Beta PAK antibody
    • bPAK antibody
    • CDKN1A antibody
    • Gamma PAK antibody
    • hPAK3 antibody
    • MRX30 antibody
    • MRX47 antibody
    • Oligophrenin 3 antibody
    • OPHN3 antibody
    • P21 (CDKN1A) activated kinase 2 antibody
    • P21 (CDKN1A) activated kinase 3 antibody
    • p21 activated kinase 1 antibody
    • p21 activated kinase 2 antibody
    • p21 activated kinase 3 antibody
    • P21 protein (Cdc42/Rac) activated kinase 1 antibody
    • P21 protein (Cdc42/Rac) activated kinase 2 antibody
    • P21 protein (Cdc42/Rac) activated kinase 3 antibody
    • P21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) antibody
    • P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody
    • P58 antibody
    • P65 PAK antibody
    • p65-PAK antibody
    • PAK 2 antibody
    • PAK 3 antibody
    • PAK1 antibody
    • PAK2 antibody
    • PAK3 antibody
    • PAK3beta antibody
    • PAK65 antibody
    • PAKalpha antibody
    • PAKgamma antibody
    • S6/H4 kinase antibody
    • Serine/threonine protein kinase PAK 1 antibody
    • Serine/threonine protein kinase PAK 2 antibody
    • Serine/threonine protein kinase PAK 3 antibody
    • Serine/threonine protein kinase PAK1 antibody
    • Serine/threonine protein kinase PAK2 antibody
    • Serine/threonine protein kinase PAK3 antibody
    • Serine/threonine-protein kinase PAK 1 antibody
    • STE20 homolog, yeast antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling PAK1 + PAK2 + PAK3 with ab196834 at 1/50 dilution (left) and synthesized peptide (right).

  • All lanes : Anti-PAK1 + PAK2 + PAK3 antibody (ab196834) at 1/500 dilution

    Lane 1 : NIH/3T3 cell extract
    Lane 2 : NIH/3T3 cell extract with synthesized peptide

    Predicted band size: 61, 58, 62 kDa

  • All lanes : Anti-PAK1 + PAK2 + PAK3 antibody (ab196834) at 1/500 dilution

    Lane 1 : 293 cell extract with synthesized peptide
    Lane 2 : 293 cell extract

    Predicted band size: 61, 58, 62 kDa

References

ab196834 has not yet been referenced specifically in any publications.

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