Key features and details
- Rabbit polyclonal to PAK1 + PAK2 + PAK3 (phospho S144 + S141 + S139)
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-PAK1 + PAK2 + PAK3 (phospho S144 + S141 + S139) antibody
See all PAK1 + PAK2 + PAK3 primary antibodies
DescriptionRabbit polyclonal to PAK1 + PAK2 + PAK3 (phospho S144 + S141 + S139)
SpecificityThis antibody detects endogenous levels of PAK1 + PAK2 + PAK3 only when phosphorylated at serine 144 + 141 + 139.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Synthetic peptide corresponding to Human PAK1 + PAK2 + PAK3. A synthesized phosphopeptide derived from human PAK1 + PAK2 + PAK3 around the phosphorylation site of serine 144 + 141 + 139
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Purification notesThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Our Abpromise guarantee covers the use of ab63513 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
RelevanceIn mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death.
Cellular localizationCytoplasm. Recruited to focal adhesions upon activation
- Alpha PAK antibody
- Beta PAK antibody
- bPAK antibody
ab63513 has not yet been referenced specifically in any publications.