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Paliperidone, D2 and 5-HT2A antagonist (ab142533)

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Chemical Structure - Paliperidone, D<sub>2</sub>&nbsp;and 5-HT<sub>2A</sub> antagonist (ab142533)

    Key features and details

    • Atypical antipsychotic. Potent D2 and 5-HT2A antagonist.
    • CAS Number: 144598-75-4
    • Purity: > 98%
    • Soluble in DMSO to 10 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Paliperidone, D2 and 5-HT2A antagonist
    • Description

      Atypical antipsychotic. Potent D2 and 5-HT2A antagonist.
    • Biological description

      Atypical antipsychotic. Potent D2 and 5-HT2A antagonist (Ki = 0.4 nM for 5-HT2A). Metabolite of risperidone (Asc 393). Orally active and blood-brain barrier permeable.
    • Purity

      > 98%
    • CAS Number

      144598-75-4
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      3-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
    • Molecular weight

      426.48
    • Molecular formula

      C23H27FN4O3
    • PubChem identifier

      115237
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Dopamine
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Potassium Channels
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Dopamine Receptors
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Serotonin Receptors
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
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      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Dendrite marker
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      • Heart
      • Cardiac arrhythmias
      • Biochemicals
      • Product Range
      • New
      • Biochemicals
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      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Dopamine
      • D2
      • Antagonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Serotonin
      • 5-HT2
      • 5-HT2A
      • Antagonists
      • Metabolism
      • Types of disease
      • Obesity

    Images

    • Chemical Structure - Paliperidone, D<sub>2</sub>&nbsp;and 5-HT<sub>2A</sub> antagonist (ab142533)
      Chemical Structure - Paliperidone, D2 and 5-HT2A antagonist (ab142533)
      2D chemical structure image of ab142533, Paliperidone, D2and 5-HT2A antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab142533? Please let us know so that we can cite the reference in this datasheet.

    ab142533 has not yet been referenced specifically in any publications.

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