Paliperidone, D2 and 5-HT2A antagonist (ab142533)

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Overview

  • Product name

    Paliperidone, D2 and 5-HT2A antagonist

  • Description

    Atypical antipsychotic. Potent D2 and 5-HT2A antagonist.

  • Biological description

    Atypical antipsychotic. Potent D2 and 5-HT2A antagonist (Ki = 0.4 nM for 5-HT2A). Metabolite of risperidone (Asc 393). Orally active and blood-brain barrier permeable.

  • Purity

    > 98%

  • CAS Number

    144598-75-4

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

  • Molecular weight

    426.48

  • Molecular formula

    C23H27FN4O3

  • PubChem identifier

    115237

  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 10 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kozielska M  et al. Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res 29:1932-48 (2012). Read more (PubMed: 22437487) »
  • Nasrallah HA  et al. Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. Brain Res 1354:23-9 (2010). Read more (PubMed: 20682307) »
  • Dremencov E  et al. Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology (Berl) 194:63-72 (2007). Read more (PubMed: 17530476) »

Publishing research using ab142533? Please let us know so that we can cite the reference in this datasheet.

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