Overview

  • Product name

    Pamidronate disodium, Biphosphate compound
  • Description

    Biphosphate compound able to inhibit bone resorption
  • Biological description

    Biphosphate compound able to inhibit bone resorption by inducing apoptosis in osteoclasts. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    57248-88-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [3-Amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate disodium salt
  • Molecular weight

    279.03
  • Molecular formula

    C3H9NNa2O7P2
  • PubChem identifier

    73351
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tu W  et al. The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice. J Exp Med 208:1511-22 (2011). Read more (PubMed: 21708931) »
  • Mayahara M & Sasaki T Cellular mechanism of inhibition of osteoclastic resorption of bone and calcified cartilage by long-term pamidronate administration in ovariectomized mature rats. Anat Rec A Discov Mol Cell Evol Biol 274:817-26 (2003). Read more (PubMed: 12923892) »
  • Kaczmarczyk-Sedlak I  et al. Effect of pamidronate on the action of catecholamines on blood pressure in the marrow cavity of long bones in rats with prednisolone-induced osteoporosis. Pharmacol Rep 59:58-63 (0). Read more (PubMed: 17377207) »

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