Anti-pan-AKT (phospho T308) antibody (ab38449)

Rabbit polyclonal pan-AKT (phospho T308) antibody. Validated in WB, ELISA, IHC and tested in Mouse, Rat, Human. Cited in 101 publication(s). Independently reviewed in 5 review(s).

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ab38449 has been referenced in 165 publications.

  • Dong L  et al. LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin ß3 axis. J Cell Biochem 120:4851-4862 (2019). PubMed: 30623482
  • Yuan YH  et al. Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Commun Signal 17:9 (2019). PubMed: 30683109
  • Xing Y & Li L Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21. Int J Biochem Cell Biol 109:8-16 (2019). PubMed: 30684569
  • Sun D  et al. PUF60 accelerates the progression of breast cancer through downregulation of PTEN expression. Cancer Manag Res 11:821-830 (2019). PubMed: 30697074
  • Li Z  et al. GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. Biochem Biophys Res Commun 510:339-344 (2019). PubMed: 30722993
  • Tang H  et al. miR-505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT-NF?B pathway in NSCLC cells. Int J Mol Med 43:1203-1216 (2019). PubMed: 30628663
  • Jiang R  et al. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a. Int Immunopharmacol 69:373-381 (2019). PubMed: 30776646
  • Wei W  et al. miR-600 inhibits lung cancer via downregulating the expression of METTL3. Cancer Manag Res 11:1177-1187 (2019). PubMed: 30774445
  • Xin M  et al. Chinese herbal decoction of Wenshen Yangxue formula improved fertility and pregnancy rate in mice through PI3K/Akt signaling. J Cell Biochem 120:3082-3090 (2019). PubMed: 30474873
  • Li H  et al. Salidroside inhibits the growth, migration and invasion of Wilms' tumor cells through down-regulation of miR-891b. Life Sci 222:60-68 (2019). PubMed: 30822424
  • Zhang X  et al. Overexpression of E74-Like Factor 5 (ELF5) Inhibits Migration and Invasion of Ovarian Cancer Cells. Med Sci Monit 25:856-865 (2019). PubMed: 30696803
  • Zhang Z  et al. Luteolin protects PC-12 cells from H2O2-induced injury by up-regulation of microRNA-21. Biomed Pharmacother 112:108698 (2019). PubMed: 30802826
  • Wang Q  et al. Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway. Cancer Lett 451:68-78 (2019). PubMed: 30849479
  • Ye Y  et al. UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway. Cancer Manag Res 11:2339-2348 (2019). PubMed: 30962721
  • Shu F  et al. Stathmin gene silencing suppresses proliferation, migration and invasion of gastric cancer cells via AKT/sCLU and STAT3 signaling. Int J Oncol 54:1086-1098 (2019). PubMed: 30628664
  • He C  et al. LncRNA UCA1 acts as a sponge of miR-204 to up-regulate CXCR4 expression and promote prostate cancer progression. Biosci Rep 39:N/A (2019). PubMed: 30940776
  • Luo S  et al. Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway. Exp Mol Med 51:37 (2019). PubMed: 30911000
  • Bao H  et al. Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5. Biomed Pharmacother 109:1826-1833 (2019). PubMed: 30551437
  • Xue F  et al. Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1 by up-regulation of miR-449a. Biomed Pharmacother 109:1951-1959 (2019). PubMed: 30551450
  • Yuan X  et al. Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood-Spinal Cord Barrier After Spinal Cord Injury in Mice. Front Neurosci 13:319 (2019). PubMed: 31040762
  • Coronel-Hernández J  et al. Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. Cancer Cell Int 19:80 (2019). PubMed: 30983885
  • Cao J  et al. PGC-1ß cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells. Cancer Cell Int 19:93 (2019). PubMed: 31007610
  • Wang T  et al. Let-7a-5p may participate in the pathogenesis of diabetic nephropathy through targeting HMGA2. Mol Med Rep 19:4229-4237 (2019). PubMed: 30896854
  • Chen Q  et al. Acteoside inhibits autophagic apoptosis of retinal ganglion cells to rescue glaucoma-induced optic atrophy. J Cell Biochem 120:13133-13140 (2019). PubMed: 31021425
  • Rui QH  et al. Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells. Braz J Med Biol Res 52:e7728 (2019). PubMed: 30994730
  • Yuan Y & Zheng Z Geniposide protects PC-12 cells against oxygen and glucose deprivation-induced injury by up-regulation of long-noncoding RNA H19. Life Sci 216:176-182 (2019). PubMed: 30472296
  • Deng R  et al. lncRNA SNHG1 negatively regulates miRNA-101-3p to enhance the expression of ROCK1 and promote cell proliferation, migration and invasion in osteosarcoma. Int J Mol Med 43:1157-1166 (2019). PubMed: 30592267
  • Zhao HY  et al. Diprophylline inhibits non-small cell lung cancer A549 cell proliferation and migration, and promotes apoptosis, by downregulating PI3K signaling pathway. Oncol Lett 17:857-862 (2019). PubMed: 30655839
  • Sui G  et al. Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer. Oncol Lett 17:944-950 (2019). PubMed: 30655852
  • Wang Y  et al. Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes. Front Physiol 10:167 (2019). PubMed: 30873046
  • Liu Y  et al. The overexpression of Rab9 promotes tumor progression regulated by XBP1 in breast cancer. Onco Targets Ther 12:1815-1824 (2019). PubMed: 30881034
  • Zhao W  et al. Transcription factor ATF3 mediates the radioresistance of breast cancer. J Cell Mol Med 22:4664-4675 (2018). PubMed: 30117642
  • Zhu B  et al. Downregulation of Krüppel-like factor 1 inhibits the metastasis and invasion of cervical cancer cells. Mol Med Rep 18:3932-3940 (2018). PubMed: 30132534
  • Xie X  et al. Long non-coding RNA, CHRF, predicts poor prognosis of lung adenocarcinoma and promotes cell proliferation and migration. Oncol Lett 16:6245-6252 (2018). PubMed: 30333887
  • Zhang XL  et al. Puerarin 6?-O-xyloside possesses significant antitumor activities on colon cancer through inducing apoptosis. Oncol Lett 16:5557-5564 (2018). PubMed: 30344709
  • He P  et al. UBA2 promotes proliferation of colorectal cancer. Mol Med Rep 18:5552-5562 (2018). PubMed: 30387828
  • Yin D  et al. Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124. Cell Physiol Biochem 50:2188-2202 (2018). PubMed: 30415256
  • Qi K & Zhong J LncRNA HOTAIR improves diabetic cardiomyopathy by increasing viability of cardiomyocytes through activation of the PI3K/Akt pathway. Exp Ther Med 16:4817-4823 (2018). PubMed: 30542437
  • Sun C  et al. Long non-coding RNA SNHG20 promotes nasopharyngeal carcinoma cell migration and invasion by upregulating TGF-ß1. Exp Ther Med 16:4967-4974 (2018). PubMed: 30546404
  • Dang X  et al. The diagnostic value and pathogenetic role of lncRNA-ATB in patients with osteoarthritis. Cell Mol Biol Lett 23:55 (2018). PubMed: 30505322
  • Wu R  et al. Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells (ASCs) osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway. Stem Cell Res Ther 9:348 (2018). PubMed: 30545407
  • Yang P  et al. miR-140-5p regulates cell migration and invasion of non-small cell lung cancer cells through targeting VEGFA. Mol Med Rep 18:2866-2872 (2018). PubMed: 30015904
  • Li F  et al. CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells. Oncol Lett 15:4789-4796 (2018). PubMed: 29552118
  • Yuan Y  et al. Proliferative role of BDNF/TrkB signaling is associated with anoikis resistance in cervical cancer. Oncol Rep 40:621-634 (2018). PubMed: 29989647
  • Zhou Z  et al. Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia-reperfusion injury via upregulation of the PI3K/Akt pathway. Mol Med Rep 18:1560-1570 (2018). PubMed: 29901074
  • Zhou Q  et al. Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway. J Cell Biochem 119:806-816 (2018). PubMed: 28657671
  • Zhang H & Hu N Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway. Mol Med Rep 18:1345-1352 (2018). PubMed: 29901196
  • Zheng W & Guan J Oncostatin M promotes the osteogenic differentiation of mouse MC3T3-E1osteoblasts through the regulation of monocyte chemotactic protein-1. Mol Med Rep 18:2523-2530 (2018). PubMed: 30015860
  • Qu R  et al. Ghrelin protects against osteoarthritis through interplay with Akt and NF-?B signaling pathways. FASEB J 32:1044-1058 (2018). PubMed: 29070587
  • Bao J  et al. Fmr1 protects cardiomyocytes against lipopolysaccharide-induced myocardial injury. Exp Ther Med 16:1825-1833 (2018). PubMed: 30186407
  • Shi J  et al. Phosphatidylinositol 3-kinase-mediated HO-1/CO represses Fis1 levels and alleviates lipopolysaccharide-induced oxidative injury in alveolar macrophages. Exp Ther Med 16:2735-2742 (2018). PubMed: 30210614
  • Li G  et al. Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5. Biosci Rep 38:N/A (2018). PubMed: 30232236
  • Yu X  et al. Osteopontin promotes hepatocellular carcinoma progression via the PI3K/AKT/Twist signaling pathway. Oncol Lett 16:5299-5308 (2018). PubMed: 30250599
  • Gong L  et al. Astragaloside IV Protects Rat Cardiomyocytes from Hypoxia-Induced Injury by Down-Regulation of miR-23a and miR-92a. Cell Physiol Biochem 49:2240-2253 (2018). PubMed: 30257251
  • Liu F  et al. CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway. Onco Targets Ther 11:6209-6216 (2018). PubMed: 30288056
  • Li X  et al. Targeting cysteine-rich angiogenic inducer-61 by antibody immunotherapy suppresses growth and migration of non-small cell lung cancer. Exp Ther Med 16:730-738 (2018). PubMed: 30116327
  • Liu Z  et al. Notoginsenoside R1 protects oxygen and glucose deprivation-induced injury by upregulation of miR-21 in cardiomyocytes. J Cell Biochem N/A:N/A (2018). PubMed: 30552708
  • Yin L  et al. Analysis of PTEN expression and promoter methylation in Uyghur patients with mild type 2 diabetes mellitus. Medicine (Baltimore) 97:e13513 (2018). PubMed: 30544451
  • Deng S  et al. Sesamin Protects the Femoral Head From Osteonecrosis by Inhibiting ROS-Induced Osteoblast Apoptosis in Rat Model. Front Physiol 9:1787 (2018). PubMed: 30618801
  • Jiang Y  et al. TIPE2 governs macrophage polarization via negative regulation of mTORC1. Mol Med Rep 17:952-960 (2018). PubMed: 29115630
  • Zhang J  et al. Down-regulation of HIF-1a inhibits the proliferation, migration, and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression. Biosci Rep 38:N/A (2018). PubMed: 29899167
  • Jiang MP  et al. ß-arrestin 2 attenuates lipopolysaccharide-induced liver injuryviainhibition of TLR4/NF-?B signaling pathway-mediated inflammation in mice. World J Gastroenterol 24:216-225 (2018). PubMed: 29375207
  • Wang Y & Kong D LncRNA GAS5 Represses Osteosarcoma Cells Growth and Metastasis via Sponging MiR-203a. Cell Physiol Biochem 45:844-855 (2018). PubMed: 29414815
  • Wu W  et al. Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells. Oncol Lett 15:2227-2235 (2018). PubMed: 29434929
  • Yan B  et al. Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway. Exp Ther Med 15:4829-4837 (2018). PubMed: 29805503
  • Jin J  et al. miR-448 targets Rab2B and is pivotal in the suppression of pancreatic cancer. Oncol Rep 40:1379-1389 (2018). PubMed: 30015954
  • Zhong X  et al. Long noncoding RNA kcna3 inhibits the progression of colorectal carcinoma through down-regulating YAP1 expression. Biomed Pharmacother 107:382-389 (2018). PubMed: 30099342
  • Liu Y  et al. Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. Int J Mol Med 42:3037-3046 (2018). PubMed: 30272367
  • Yang Y  et al. Long noncoding RNA TUG1 promotes renal cell carcinoma cell proliferation, migration and invasion by downregulating microRNA-196a. Mol Med Rep 18:5791-5798 (2018). PubMed: 30387842
  • Li BH  et al. Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. Med Sci Monit 24:8105-8114 (2018). PubMed: 30418964
  • Liu Y  et al. MicroRNA-200a Affects the Proliferation of Airway Smooth Muscle Cells and Airway Remodeling by Targeting FOXC1 via the PI3K/AKT Signaling Pathway in Ovalbumin-Induced Asthmatic Mice. Cell Physiol Biochem 50:2365-2389 (2018). PubMed: 30423573
  • Meng H  et al. Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction. J Cell Physiol N/A:N/A (2018). PubMed: 30456911
  • He D  et al. Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis. Med Sci Monit 24:8391-8400 (2018). PubMed: 30459299
  • Chen X  et al. Microtia patients: Auricular chondrocyte ECM is promoted by CGF through IGF-1 activation of the IGF-1R/PI3K/AKT pathway. J Cell Physiol N/A:N/A (2018). PubMed: 30471105
  • Abou-Antoun TJ  et al. Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance. PLoS One 13:e0189711 (2018). PubMed: 29298329
  • Yang GS  et al. mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia. Mol Med Rep 17:5821-5829 (2018). PubMed: 29484389
  • Wang X  et al. Tunicamycin suppresses breast cancer cell growth and metastasis via regulation of the protein kinase B/nuclear factor-?B signaling pathway. Oncol Lett 15:4137-4142 (2018). PubMed: 29541178
  • Pan Z  et al. Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression. Oncol Lett 15:4821-4826 (2018). PubMed: 29552121
  • Zhou L  et al. Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer. Oncol Lett 15:4859-4866 (2018). PubMed: 29552125
  • Wang X  et al. Buyang Huanwu Decoction Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats via Downregulation of Related Protein and Gene Expression. Evid Based Complement Alternat Med 2018:9185485 (2018). PubMed: 29681987
  • Zhang C & Zhang J Decreased expression of microRNA-223 promotes cell proliferation in hepatocellular carcinoma cells via the insulin-like growth factor-1 signaling pathway. Exp Ther Med 15:4325-4331 (2018). PubMed: 29725374
  • Gao Z  et al. Effect of gastric bypass combined with ileal transportation on type 2 diabetes mellitus. Exp Ther Med 15:4571-4577 (2018). PubMed: 29725390
  • Zhang Y  et al. miR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1. Oncol Lett 15:7243-7248 (2018). PubMed: 29725442
  • Zhang W  et al. ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. Placenta 63:7-14 (2018). WB . PubMed: 29486856
  • Wang Z  et al. Long noncoding RNA maternally expressed gene 3 knockdown alleviates lipopolysaccharide-induced inflammatory injury by up-regulation of miR-203 in ATDC5 cells. Biomed Pharmacother 100:240-249 (2018). WB . PubMed: 29432995
  • Zhang H  et al. The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3. Biomed Pharmacother 102:626-632 (2018). PubMed: 29602130
  • Feng FB & Qiu HY Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis. Biomed Pharmacother 102:1209-1220 (2018). WB, IHC . PubMed: 29710540
  • Nan W  et al. Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. Biomed Res Int 2018:6473580 (2018). PubMed: 29770336
  • Zhang DD  et al. Vildagliptin, a DPP4 inhibitor, alleviates diabetes-associated cognitive deficits by decreasing the levels of apoptosis-related proteins in the rat hippocampus. Exp Ther Med 15:5100-5106 (2018). PubMed: 29805536
  • Zhou J  et al. MiR-128-3p directly targets VEGFC/VEGFR3 to modulate the proliferation of lymphatic endothelial cells through Ca2+ signaling. Int J Biochem Cell Biol N/A:N/A (2018). WB ; Human . PubMed: 29777777
  • Xu Y  et al. Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223. Biomed Pharmacother 104:509-519 (2018). WB . PubMed: 29800915
  • Yan R  et al. Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells. Biomed Pharmacother 103:1490-1497 (2018). WB ; Rat . PubMed: 29864934
  • Xin Y  et al. Resveratrol improves uric acid-induced pancreatic ß-cells injury and dysfunction through regulation of miR-126. Biomed Pharmacother 102:1120-1126 (2018). WB . PubMed: 29710530
  • Han W & Liu J LncRNA-p21 inhibited the proliferation of osteosarcoma cells via the miR-130b/PTEN/AKT signaling pathway. Biomed Pharmacother 97:911-918 (2018). WB . PubMed: 29136769
  • Nielsen TL  et al. Exercising with blocked muscle glycogenolysis: Adaptation in the McArdle mouse. Mol Genet Metab 123:21-27 (2018). WB . PubMed: 29174367
  • Qu X  et al. Downregulation of TBC1 Domain Family Member 24 (BC1D24) Inhibits Breast Carcinoma Growth via IGF1R/PI3K/AKT Pathway. Med Sci Monit 24:3987-3996 (2018). PubMed: 29893377
  • Wang X  et al. Downregulation of YAP inhibits proliferation, invasion and increases cisplatin sensitivity in human hepatocellular carcinoma cells. Oncol Lett 16:585-593 (2018). PubMed: 29928445
  • Zhang Y  et al. TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer. Int J Oncol 53:620-632 (2018). PubMed: 29767249
  • Li BS  et al. Camptothecin inhibits the progression of NPC by regulating TGF-ß-induced activation of the PI3K/AKT signaling pathway. Oncol Lett 16:552-558 (2018). PubMed: 29963130
  • Zhang H  et al. Inhibition of the PI3K/Akt signaling pathway reverses sorafenib-derived chemo-resistance in hepatocellular carcinoma. Oncol Lett 15:9377-9384 (2018). PubMed: 29928334
  • Chen X  et al. Knockdown of RWD domain containing 3 inhibits the malignant phenotypes of glioblastoma cells via inhibition of phosphoinositide 3-kinase/protein kinase B signaling. Exp Ther Med 16:384-393 (2018). PubMed: 29977365
  • Li J  et al. Fibulin-3 knockdown inhibits cervical cancer cell growth and metastasis in vitro and in vivo. Sci Rep 8:10594 (2018). PubMed: 30006571
  • Kurosawa K  et al. Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D -driven tumor promotion. Cancer Sci 109:2178-2187 (2018). PubMed: 29758119
  • Wu XM  et al. MicroRNA-339-3p alleviates inflammation and edema and suppresses pulmonary microvascular endothelial cell apoptosis in mice with severe acute pancreatitis-associated acute lung injury by regulating Anxa3 via the Akt/mTOR signaling pathway. J Cell Biochem 119:6704-6714 (2018). PubMed: 29693276
  • Hu J  et al. Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane-inhibited aggressiveness of hepatic carcinoma. Mol Med Rep 18:184-192 (2018). PubMed: 29749446
  • Yang T  et al. lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line. Braz J Med Biol Res 51:e7046 (2018). PubMed: 29791590
  • Huang XY  et al. Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma. Oncotarget 8:95450-95465 (2017). PubMed: 29221140
  • Li L  et al. Expression of the ß3 subunit of Na+/K+-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway. Oncotarget 8:84285-84299 (2017). PubMed: 29137423
  • Ross JL  et al. 5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins. Sci Rep 7:15593 (2017). PubMed: 29142297
  • Zheng Y  et al. The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a. PeerJ 5:e3627 (2017). WB ; Human . PubMed: 28852584
  • Luo J  et al. Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-?B signaling pathwaysin vitro. Exp Ther Med 14:3623-3631 (2017). PubMed: 29042957
  • Liu Y  et al. The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway. Oncol Lett 13:4685-4690 (2017). PubMed: 28599470
  • Shi Y  et al. SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population. Cancer Cell Int 17:81 (2017). PubMed: 28924391
  • Wang P  et al. Long Noncoding RNA H19 Inhibits Cell Viability, Migration, and Invasion Via Downregulation of IRS-1 in Thyroid Cancer Cells. Technol Cancer Res Treat 16:1102-1112 (2017). PubMed: 29332545
  • Zhang W  et al. LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway. Oncotarget 8:113847-113857 (2017). PubMed: 29371951
  • Li R  et al. Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. Oncotarget 8:19354-19364 (2017). WB ; Human . PubMed: 28423613
  • Li Y  et al. MicroRNA-210 induces endothelial cell apoptosis by directly targeting PDK1 in the setting of atherosclerosis. Cell Mol Biol Lett 22:3 (2017). WB . PubMed: 28536634
  • Wang C  et al. Neuroprotective mechanisms of miR-124 activating PI3K/Akt signaling pathway in ischemic stroke. Exp Ther Med 13:3315-3318 (2017). WB . PubMed: 28587406
  • Deng YP  et al. Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells. Exp Ther Med 14:753-758 (2017). PubMed: 28672995
  • Yu J  et al. miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. Med Sci Monit 23:71-77 (2017). PubMed: 28057912
  • Lu H  et al. Decreased phosphorylation of PDGFR-ß impairs the angiogenic potential of expanded endothelial progenitor cells via the inhibition of PI3K/Akt signaling. Int J Mol Med 39:1492-1504 (2017). WB ; Human . PubMed: 28487975
  • Zhang D  et al. Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway. Int J Oncol 50:1513-1530 (2017). WB ; Human . PubMed: 28339091
  • Chen S  et al. Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways. Oncol Lett 14:4659-4662 (2017). WB ; Human . PubMed: 29085464
  • Chen L  et al. Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy induction. Oncotarget 8:93878-93898 (2017). PubMed: 29212196
  • Song Z  et al. Overexpression and biological function of MEF2D in human pancreatic cancer. Am J Transl Res 9:4836-4847 (2017). PubMed: 29218083
  • Xu W  et al. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PLoS One 12:e0172477 (2017). PubMed: 28225806
  • Wu DP  et al. MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4?. Cell Physiol Biochem 43:2010-2021 (2017). PubMed: 29055957
  • Wu HB  et al. Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. Autophagy 13:1528-1542 (2017). PubMed: 28812437
  • Guo W  et al. Neurotrophin-4 induces myelin protein zero expression in cultured Schwann cells via the TrkB/PI3K/Akt/mTORC1 pathway. Anim Cells Syst (Seoul) 21:84-92 (2017). PubMed: 30460055
  • Wang K  et al. The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration. Lab Invest 97:971-982 (2017). PubMed: 28394321
  • Liu L  et al. Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways. Cell Physiol Biochem 43:52-68 (2017). PubMed: 28848091
  • Li HB  et al. Long Non-Coding RNA-MALAT1 Mediates Retinal Ganglion Cell Apoptosis Through the PI3K/Akt Signaling Pathway in Rats with Glaucoma. Cell Physiol Biochem 43:2117-2132 (2017). PubMed: 29065394
  • Yang X  et al. Panax Notoginseng Saponins attenuates sevoflurane-induced nerve cell injury by modulating AKT signaling pathway. Mol Med Rep 16:7829-7834 (2017). PubMed: 28944861
  • Duan J  et al. Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors. Oncol Rep 38:2267-2276 (2017). PubMed: 28791414
  • Guo YY  et al. Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma. Lab Invest 97:1400-1411 (2017). PubMed: 28825695
  • Sun T  et al. MiR-146a Aggravates LPS-Induced Inflammatory Injury by Targeting CXCR4 in the Articular Chondrocytes. Cell Physiol Biochem 44:1282-1294 (2017). PubMed: 29183039
  • Fu J  et al. 1, 6-di-O-caffeoyl-ß-D-glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation. Phytomedicine 36:273-282 (2017). PubMed: 29157825
  • Gong HY  et al. Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway. Int J Mol Med 38:943-50 (2016). PubMed: 27430327
  • Pan F  et al. Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1. Int J Mol Med 38:1507-1514 (2016). PubMed: 28026003
  • Lv B  et al. Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury. Front Cell Neurosci 10:283 (2016). PubMed: 28018176
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