Key features and details
- Rabbit polyclonal to pan Sodium Channel
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-pan Sodium Channel antibody
DescriptionRabbit polyclonal to pan Sodium Channel
SpecificityDetects endogenous levels of total sodium channel protein.
Tested applicationsSuitable for: ELISA, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human pan Sodium Channel.
- Extracts from HuvEc cells.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab53724 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa).|
RelevanceThe pan sodium ion channel, SCN5A, is a cardiac sodium channel distinct from those in nerve and muscle. It is a tetrodotoxin-resistant Na(+) channel isoform. SCN5A mediates the voltage-dependent sodium ion permeability of excitable membranes by opening or closing in response to the voltage difference across the membrane. Na(+) ions pass in accordance with their electrochemical gradient. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram. Defects in SCN5A are involved in many diseases including: progressive familial heart block type I (PFHBI), also known as Lenegre-Lev disease or progressive cardiac conduction defect (PCCD); long QT syndrome type 3 (LQT3); Brugada syndrome; sick sinus syndrome 1 (SSS1); idiopathic ventricular fibrillation (IVF), also called paroxysmal familial ventricular fibrillation; sudden infant death syndrome (SIDS); familial atrial standstill and dilated cardiomyopathy 1E (CMD1E).
Cellular localizationCell Membrane; Multi-pass membrane protein.
- HBSC II antibody
- HH1 antibody
- hNaN antibody
ab53724 has not yet been referenced specifically in any publications.