Overview

  • Product name

    Panaxadiol, Anticancer agent
  • Description

    Anticancer agent
  • Biological description

    Anticancer agent. Induces caspase-3- and caspase-9-mediated apoptosis. Shows radioprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    19666-76-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-Pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
  • Molecular weight

    460.74
  • Molecular formula

    C30H52O3
  • PubChem identifier

    73498
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
  • Source

    Panax ginseng

  • Research areas

References

This product has been referenced in:

  • Du GJ  et al. The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res 27:272-7 (2013). Read more (PubMed: 22566066) »
  • Du GJ  et al. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. J Pharm Pharmacol 64:727-34 (2012). Read more (PubMed: 22471369) »
  • Lee HJ  et al. In Vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides. Phytother Res 20:392-5 (2006). Read more (PubMed: 16619368) »
  • Niu YP  et al. [Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi 24:127-9, 132 (2004). Read more (PubMed: 15015445) »

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