Overview

  • Product name

  • Description

    Rabbit polyclonal to PANK1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 207-483 of Human PANK1.

  • Positive control

    • 293T, A431, H1299, HeLa S3, HepG2, Molt-4, Raji cells, NCIN87 xenograft

Properties

Applications

Our Abpromise guarantee covers the use of ab96173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 64 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function

    Plays a role in the physiological regulation of the intracellular CoA concentration.
  • Tissue specificity

    Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
  • Pathway

    Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
  • Sequence similarities

    Belongs to the type II pantothenate kinase family.
  • Domain

    The N-terminal extension, present in isoform 1 may be the regulatory domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • coaA antibody
    • hPanK antibody
    • hPanK1 antibody
    • PANK antibody
    • PANK1 antibody
    • PANK1_HUMAN antibody
    • PANK1a antibody
    • PANK1b antibody
    • PanK1beta antibody
    • Pantothenate kinase 1 antibody
    • Pantothenate kinase antibody
    • Pantothenic acid kinase 1 antibody
    see all

Images

  • Anti-PANK1 antibody (ab96173) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 64 kDa



    7.5% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using ab96173 at 1/500 dilution.

References

This product has been referenced in:

  • Machado MV  et al. Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model. Dig Dis Sci 61:137-48 (2016). Read more (PubMed: 26403427) »
See 1 Publication for this product

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