Key features and details
- Rabbit polyclonal to PAPP A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PAPP A antibody
See all PAPP A primary antibodies
DescriptionRabbit polyclonal to PAPP A
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Synthetic peptide within Human PAPP A (internal sequence). The exact sequence is proprietary. Gene Accession: NP_002572.
Database link: Q13219
- IHC-P: Human ovarian cancer tissue and Human thyroid cancer tissue.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab200374 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionMetalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Tissue specificityHigh levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
Sequence similaritiesBelongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains.
Developmental stagePresent in serum and placenta during pregnancy; levels increase throughout pregnancy.
modificationsThere appear to be no free sulfhydryl groups.
- Information by UniProt
- ASBABP2 antibody
- Aspecific BCL2 ARE binding protein 2 antibody
- Differentially placenta 1 expressed protein antibody
ab200374 has not yet been referenced specifically in any publications.