Overview

  • Product name

    Paprotrain, MKLP-2 inhibitor
  • Description

    Selective cell-permeable MKLP-2 inhibitor. ATPase and Aurora B inhibitor.
  • Biological description

    Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC50 values are 1.35 and 0.83 µM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.
  • Purity

    > 98%
  • CAS Number

    57046-73-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhang Y  et al. KIF20A regulates porcine oocyte maturation and early embryo development. PLoS One 9:e102898 (2014). Read more (PubMed: 25036038) »
  • Liu J  et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol 11:117 (2013). Read more (PubMed: 24359300) »
  • Tcherniuk S  et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl 49:8228-31 (2010). Read more (PubMed: 20857469) »

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