Overview

  • Product name

  • Description

    Rabbit polyclonal to PAR2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human, Chimpanzee, Monkey
  • Immunogen

    Synthetic peptide conjugated to KLH, from a region within amino acids 347-363 of Human PAR2.

  • Positive control

    • Rat hippocampus lysate.
  • General notes

    Briefly centrifuge ab124227 to collect liquid before opening the vial. Heat the tube in 90°C water bath for 1-2 minutes to dissolve any precipitate before use.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Contains antibody stabilization buffer.
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab123227 is purified on an antigen-based affinity column.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250. Detects a band of approximately 49-52 kDa (predicted molecular weight: 44 kDa).
IP 1/200.

Target

  • Function

    Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
  • Tissue specificity

    Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Coagulation factor II receptor like 1 antibody
    • Coagulation factor II receptor-like 1 antibody
    • Coagulation factor II thrombin receptor like 1 antibody
    • F2RL1 antibody
    • G protein coupled receptor 11 antibody
    • G-protein coupled receptor 11 antibody
    • GPR11 antibody
    • PAR 2 antibody
    • PAR-2 antibody
    • PAR2_HUMAN antibody
    • Protease activated receptor 2 antibody
    • Proteinase activated receptor 2 antibody
    • Proteinase-activated receptor 2 antibody
    • Thrombin receptor like 1 antibody
    • Thrombin receptor-like 1 antibody
    see all

References

This product has been referenced in:

  • Sokolina K  et al. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Mol Syst Biol 13:918 (2017). IP . Read more (PubMed: 28298427) »
See 1 Publication for this product

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