Overview

  • Product name

  • Description

    Rabbit polyclonal to PAR2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Guinea pig, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 347-396 (VSHDFRDHAK NALLCRSVRT VKQMQVSLTS KKHSRKSSSY SSSSTTVKTS) of Human PAR2 (NP_005233).

  • Positive control

    • MCF7 cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab128628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
  • Tissue specificity

    Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Coagulation factor II receptor like 1 antibody
    • Coagulation factor II receptor-like 1 antibody
    • Coagulation factor II thrombin receptor like 1 antibody
    • F2RL1 antibody
    • G protein coupled receptor 11 antibody
    • G-protein coupled receptor 11 antibody
    • GPR11 antibody
    • PAR 2 antibody
    • PAR-2 antibody
    • PAR2_HUMAN antibody
    • Protease activated receptor 2 antibody
    • Proteinase activated receptor 2 antibody
    • Proteinase-activated receptor 2 antibody
    • Thrombin receptor like 1 antibody
    • Thrombin receptor-like 1 antibody
    see all

Images

  • Anti-PAR2 antibody (ab128628) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Predicted band size: 44 kDa



    Gel concentration: 12%

References

This product has been referenced in:

  • Klinngam W  et al. Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells. Int J Mol Sci 19:N/A (2018). Read more (PubMed: 30423938) »
  • Bakele M  et al. An Interactive Network of Elastase, Secretases, and PAR-2 Protein Regulates CXCR1 Receptor Surface Expression on Neutrophils. J Biol Chem 289:20516-20525 (2014). WB ; Human . Read more (PubMed: 24914212) »
See all 2 Publications for this product

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