Overview

  • Product name

    Parasin I, Histone H2A derivative
  • Description

    Potent cationic antimicrobial peptide. Histone H2A derivative.
  • Biological description

    Potent cationic antimicrobial peptide. Histone H2A derivative. Generates from procathepsin D and a metalloprotease in epidermal tissue. Shows membrane-permeabilizing activity in vivo.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    2000.36
  • Molecular formula

    C82H154N34O24
  • Sequence

    KGRGKQGGKVRAKAKTRSS
  • PubChem identifier

    16198073
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(CCCCN)NC(=O)CNC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCCCN)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Koo YS  et al. Structure-activity relations of parasin I, a histone H2A-derived antimicrobial peptide. Peptides 29:1102-8 (2008). Read more (PubMed: 18406495) »
  • Cho JH  et al. Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish. FASEB J 16:429-31 (2002). Read more (PubMed: 11821259) »
  • Cho JH  et al. Matrix metalloproteinase 2 is involved in the regulation of the antimicrobial peptide parasin I production in catfish skin mucosa. FEBS Lett 531:459-63 (2002). Read more (PubMed: 12435593) »

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