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    parathyroid-hormone-antibody-ab85730.pdf

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Signal Transduction Growth Factors/Hormones Hormones
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Anti-Parathyroid Hormone antibody (ab85730)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody (ab85730)

    Key features and details

    • Goat polyclonal to Parathyroid Hormone
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Protein
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    Recombinant Human Parathyroid Hormone protein (ab51234)

    View more associated products

    Overview

    • Product name

      Anti-Parathyroid Hormone antibody
      See all Parathyroid Hormone primary antibodies
    • Description

      Goat polyclonal to Parathyroid Hormone
    • Host species

      Goat
    • Specificity

      ab85730 recognizes Parathyroid hormone amino acids 1-84, 39-84 and 53-84. Does not recognize Parathyroid hormone amino acids 1-34.
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Cat, Dog, Cynomolgus monkey
    • Immunogen

      Synthetic peptide: EWLRKKLQDV HNFVALGAPL APRDAGSQRP RK, corresponding to C terminal amino acids 53-84 of Human Parathyroid Hormone.

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Parathyroid tissue.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7.20
      Constituents: PBS, 40% Glycerol
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Growth Factors/Hormones
      • Hormones

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Positive Controls

      • Recombinant Human Parathyroid Hormone protein (ab51234)
    • Recombinant Protein

      • Recombinant Human Parathyroid Hormone protein (ab51234)

    Applications

    Our Abpromise guarantee covers the use of ab85730 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P Use a concentration of 5 µg/ml.

    Target

    • Function

      PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
    • Involvement in disease

      Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
    • Sequence similarities

      Belongs to the parathyroid hormone family.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P01270 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 403986 Dog
      • Entrez Gene: 5741 Human
      • Omim: 168450 Human
      • SwissProt: P52212 Dog
      • SwissProt: P01270 Human
      • Unigene: 37045 Human
      • Alternative names

        • hPTH antibody
        • Parathormone antibody
        • Parathyrin antibody
        • Parathyroid hormone 1 antibody
        • Parathyroid hormone antibody
        • Prepro PTH antibody
        • Preproparathyroid hormone antibody
        • PTH antibody
        • PTH1 antibody
        • PTH1 receptor antibody
        • PTH1R antibody
        • PTHR antibody
        • PTHR1 antibody
        • PTHY_HUMAN antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody (ab85730)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody (ab85730)
        Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human parathyroid tissue, staining Parathyroid Hormone with ab85730 at 5 µg/ml.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab85730? Please let us know so that we can cite the reference in this datasheet.

      ab85730 has not yet been referenced specifically in any publications.

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