Anti-Parathyroid Hormone antibody (ab85730)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Parathyroid Hormone antibody
See all Parathyroid Hormone primary antibodies -
Description
Goat polyclonal to Parathyroid Hormone -
Host species
Goat -
Specificity
ab85730 recognizes Parathyroid hormone amino acids 1-84, 39-84 and 53-84. Does not recognize Parathyroid hormone amino acids 1-34. -
Tested applications
Suitable for: ELISA, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Cat, Dog, Cynomolgus monkey
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Immunogen
Synthetic peptide: EWLRKKLQDV HNFVALGAPL APRDAGSQRP RK, corresponding to C terminal amino acids 53-84 of Human Parathyroid Hormone.
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Positive control
- Parathyroid tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Constituents: PBS, 40% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab85730 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent dilution. | |
| IHC-P | Use a concentration of 5 µg/ml. |
Target
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Function
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. -
Involvement in disease
Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. -
Sequence similarities
Belongs to the parathyroid hormone family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 403986 Dog
- Entrez Gene: 5741 Human
- Omim: 168450 Human
- SwissProt: P52212 Dog
- SwissProt: P01270 Human
- Unigene: 37045 Human
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Alternative names
- hPTH antibody
- Parathormone antibody
- Parathyrin antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody (ab85730)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human parathyroid tissue, staining Parathyroid Hormone with ab85730 at 5 µg/ml.
Protocols
Datasheets and documents
References
ab85730 has not yet been referenced specifically in any publications.
