- Datasheet
- Specific References
- Protocols
Overview
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Product nameAnti-Parathyroid Hormone antibody
See all Parathyroid Hormone primary antibodies -
DescriptionGoat polyclonal to Parathyroid Hormone
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Host speciesGoat
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Specificityab85730 recognizes Parathyroid hormone amino acids 1-84, 39-84 and 53-84. Does not recognize Parathyroid hormone amino acids 1-34.
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Tested applicationsSuitable for: ELISA, IHC-Pmore details
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Species reactivityReacts with: Human
Predicted to work with: Cat, Dog, Cynomolgus monkey
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Immunogen
Synthetic peptide: EWLRKKLQDV HNFVALGAPL APRDAGSQRP RK, corresponding to C terminal amino acids 53-84 of Human Parathyroid Hormone.
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Positive control
- Parathyroid tissue.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Storage bufferPreservative: None
Constituents: 40% Glycerol, PBS, pH 7.2 -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab85730 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent dilution. | |
| IHC-P | Use a concentration of 5 µg/ml. |
Target
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FunctionPTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
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Involvement in diseaseDefects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
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Sequence similaritiesBelongs to the parathyroid hormone family.
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Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 403986 Dog
- Entrez Gene: 5741 Human
- Omim: 168450 Human
- SwissProt: P52212 Dog
- SwissProt: P01270 Human
- Unigene: 37045 Human
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Alternative names
- hPTH antibody
- Parathormone antibody
- Parathyrin antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody (ab85730)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human parathyroid tissue, staining Parathyroid Hormone with ab85730 at 5 µg/ml.
Protocols
References
ab85730 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"