Paroxetine hydrochloride, 5-HT uptake inhibitor (ab120069)
- Datasheet
- References (2)
Overview
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Product nameParoxetine hydrochloride, 5-HT uptake inhibitor
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Description5-HT uptake inhibitor
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Biological descriptionPotent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
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Purity> 99%
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CAS Number110429-35-1
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Chemical structure
Properties
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Chemical name(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride
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Molecular weight365.83
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Molecular formulaC19H20FNO3.HCl
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Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Bourin M et al. Paroxetine: a review. CNS Drug Rev 7:25-47 (2001). Read more (PubMed: 11420571) »
- Owens MJ et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-22 (1997). Read more (PubMed: 9400006) »
- Thomas DR et al. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology (Berl) 93:193-200 (1987). Read more (PubMed: 2962217) »
