Alzheimer's disease pathway

Alzheimer's disease is the most common form of dementia. This pathway card outlines the mechanisms of formation of amyloid plaques and neurofibrillary tangles, as well as the involvement of mitochondria and microglia.

The neuropathology of Alzheimer's disease is characterized by the accumulation of amyloid plaques and neurofibrillary tangles outside and inside neurons respectively. Healthy amyloid precursor protein (APP) is cleaved to pathogenic Aβ peptides through the sequential action of α-, β- and γ-secretases. Similarly, tau protein is hyperphosphorylayed by GSK3 and other kinases to first form paired helical filaments and subsequently neurofibrillary tangles (NFTs).

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