For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome
If you continue without changing your cookie settings, we'll assume you’re happy with this.
Chemokines are classified into four groups based on the pattern of their cysteine residues, namely CXC (α chemokines), CC (β chemokines), CX3C and C. Their receptors are class A GPCRs, however not all receptors are selective for a single ligand. A chemokine may therefore bind a number of receptors and exhibit agonist behavior with some and antagonist behavior with others. Some commonly activated downstream pathways include JAK/Stat, Ras, Erk, and Akt.