Chemokine signaling pathway
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Chemokines are a family of small cytokines (~8 kDa) whose main function is to attract immune system cells at sites of inflammation. This pathway highlights the different classes of chemokines, their receptors, and how chemokine signaling activates JAK/Stat, Ras, ERK, and Akt pathways.
Chemokines are classified into four groups based on the pattern of their cysteine residues, namely CXC (α chemokines), CC (β chemokines), CX3C and C. Their receptors are class A GPCRs, however not all receptors are selective for a single ligand. A chemokine may therefore bind a number of receptors and exhibit agonist behavior with some and antagonist behavior with others. Some commonly activated downstream pathways include JAK/Stat, Ras, Erk, and Akt.