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NGF signals through at least two types of receptor; the low-affinity nerve growth factor receptor [LNGFR or p75 neurotrophin receptor (p75NTR)] and TrkA, a transmembrane tyrosine kinase. When NGF binds to TrkA, the receptor dimerizes and autophosphorylates its tyrosine kinase domain, which leads to the activation of PI3K, Ras, and PLC signaling pathways. Alternatively, p75NTR can form a heterodimer with TrkA which has higher affinity for NGF.