Overview

  • Product name
  • Description
    Rabbit polyclonal to PATL1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PATL1 aa 550-600. The exact sequence is proprietary. NP_689929.2
    Sequence:

    E RPALMDDRKH KICSMYDNLR GKLPGQERPS DDHFVQIMCI RKGKRMVARI


    Database link: Q86TB9

  • Positive control
    • HeLa cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab176729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).
    • Tissue specificity
      Ubiquitous.
    • Sequence similarities
      Belongs to the PAT1 family.
    • Domain
      The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic mRNA processing body assembly.
      The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain.
    • Cellular localization
      Cytoplasm > P-body.
    • Information by UniProt
    • Database links
    • Alternative names
      • hPat1b antibody
      • OK/KNS-cl.5 antibody
      • PAT1-like protein 1 antibody
      • Pat1b antibody
      • PATL1 antibody
      • PATL1_HUMAN antibody
      • protein associated with topoisomerase II homolog 1 antibody
      • Protein PAT1 homolog 1 antibody
      • Protein PAT1 homolog b antibody
      see all

    Images

    • Western blot of immunoprecipitates, HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) labeling PATL1 using ab176729 at 1 µg/ml, with chemiluminescence detection with an exposure time of 30 seconds.

    References

    ab176729 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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