Recombinant

Recombinant Anti-PAX5 antibody [rPAX5/2060] (ab234402)

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Overview

  • Product name

    Anti-PAX5 antibody [rPAX5/2060]
    See all PAX5 primary antibodies

  • Description

    Mouse monoclonal [rPAX5/2060] to PAX5

  • Host species

    Mouse

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant full length protein corresponding to Human Pax5.
    Database link: Q02548

  • Positive control

    • IHC-P: Human lymph node tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab234402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

(Primary incubation for 30 minutes at room temperature).

Target

  • Function

    May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

  • Involvement in disease

    A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
    Leukemia, acute lymphoblastic, 3

  • Sequence similarities

    Contains 1 paired domain.

  • Developmental stage

    Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

  • Post-translational
    modifications

    O-glycosylated.

  • Cellular localization

    Nucleus.
  • Information by UniProt

  • Database links

    • Alternative names

      • B cell lineage specific activator antibody
      • B cell lineage specific activator protein antibody
      • B cell specific activator protein antibody
      • B cell specific transcription factor antibody
      • B-cell-specific transcription factor antibody
      • BSAP antibody
      • EBB-1 antibody
      • KLP antibody
      • Paired box 5 antibody
      • Paired box gene 5 (B cell lineage specific activator protein) antibody
      • Paired box gene 5 (B cell lineage specific activator) antibody
      • Paired box gene 5 antibody
      • Paired box homeotic gene 5 antibody
      • Paired box protein Pax 5 antibody
      • Paired box protein Pax-5 antibody
      • Paired domain gene 5 antibody
      • PAX 5 antibody
      • PAX5 antibody
      • PAX5_HUMAN antibody
      • Transcription factor PAX 5 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pax5 antibody [rPAX5/2060] (ab234402)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pax5 antibody [rPAX5/2060] (ab234402)

      Formalin-fixed, paraffin-embedded human lymph node tissue stained for Pax5 with ab234402 at 1 µg/ml in immunohistochemical analysis.

    References

    ab234402 has not yet been referenced specifically in any publications.

    Publishing research using ab234402? Please let us know so that we can cite the reference in this datasheet.

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