Overview

  • Product name

    Anti-PAX7 antibody [PAX7/497] - BSA and Azide free
    See all PAX7 primary antibodies
  • Description

    Mouse monoclonal [PAX7/497] to PAX7 - BSA and Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cyt, WB, IHC-Fr, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Chicken, Human, Zebrafish
  • Immunogen

    Recombinant fragment corresponding to Human PAX7 aa 301-505.
    Database link: P23759

  • Positive control

    • HeLa, Jurkat, A431, MCF7, U2OS or NIH 3T3 cells. Rhabdomyosarcoma (RMS)

Properties

Applications

Our Abpromise guarantee covers the use of ab212697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.5-1µg for 106 cells.

in 0.1ml volume

WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 56 kDa.
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.

for 30 minutes at RT

ICC/IF Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Probable transcription factor. May have a role in myogenesis.
  • Involvement in disease

    Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.
  • Sequence similarities

    Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 paired domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ37460 antibody
    • HUP1 antibody
    • OTTHUMP00000002534 antibody
    • Paired box 7 antibody
    • Paired box gene 7 antibody
    • Paired box homeotic gene 7 antibody
    • Paired box protein Pax-7 antibody
    • Paired domain gene 7 antibody
    • Paired domain gene HuP1 antibody
    • Pax7 antibody
    • PAX7 transcriptional factor antibody
    • PAX7/FKHR fusion gene, included antibody
    • PAX7_HUMAN antibody
    • PAX7B antibody
    • RGD1564360 antibody
    • RMS2 antibody
    see all

Images

  • Anti-PAX7 antibody [PAX7/497] - BSA and Azide free (ab212697) at 1 µg/ml + HeLa cell lysate

    Predicted band size: 56 kDa

References

ab212697 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab212697.
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