Recombinant Anti-Paxillin antibody [Y113] (ab32084)

Rabbit recombinant monoclonal Paxillin antibody [Y113]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Cow, Dog, Human. Cited in 63 publication(s).

Publishing research using ab32084? Please let us know so that we can cite the reference in this datasheet.

ab32084 has been referenced in 75 publications.

  • Gao Q  et al. Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer. J Exp Med 216:688-703 (2019). PubMed: 30710055
  • Nam S  et al. Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies. Biomaterials 200:15-24 (2019). PubMed: 30743050
  • Frank AC  et al. Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype. Nat Commun 10:1135 (2019). PubMed: 30850595
  • Pokharel SM  et al. Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nat Commun 10:1482 (2019). PubMed: 30931941
  • Tsygankova OM & Keen JH A unique role for clathrin light chain A in cell spreading and migration. J Cell Sci 132:N/A (2019). PubMed: 30975920
  • McKenzie AJ  et al. The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation. Sci Rep 8:7228 (2018). PubMed: 29740072
  • Wu KH  et al. The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. J Food Drug Anal 26:221-231 (2018). WB ; Human . PubMed: 29389559
  • Colburn ZT & Jones JCR Complexes of a6ß4 integrin and vimentin act as signaling hubs to regulate epithelial cell migration. J Cell Sci 131:N/A (2018). PubMed: 29976561
  • De Pascalis C  et al. Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts. J Cell Biol 217:3031-3044 (2018). PubMed: 29980627
  • Zhao R  et al. Endothelial cells promote metastasis of prostate cancer by enhancing autophagy. J Exp Clin Cancer Res 37:221 (2018). PubMed: 30200999
  • Zimmerman SE  et al. Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli. J Am Soc Nephrol 29:1128-1140 (2018). PubMed: 29335243
  • Mkrtschjan MA  et al. Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography. J Cell Physiol 233:3672-3683 (2018). PubMed: 29034471
  • Charrier EE  et al. Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nat Commun 9:449 (2018). PubMed: 29386514
  • Lai H  et al. FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer. J Exp Clin Cancer Res 37:32 (2018). PubMed: 29458390
  • Ng PK  et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell 33:450-462.e10 (2018). PubMed: 29533785
  • Mohagheghian E  et al. Quantifying compressive forces between living cell layers and within tissues using elastic round microgels. Nat Commun 9:1878 (2018). PubMed: 29760452
  • Gonzalez-Molina J  et al. Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration. Biomaterials 177:113-124 (2018). WB . PubMed: 29886384
  • Zhang YL  et al. Integrin a9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling. J Immunol Res 2018:4602570 (2018). PubMed: 29951557
  • Shen J  et al. Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer. J Exp Clin Cancer Res 37:175 (2018). PubMed: 30055645
  • Chizhik AM  et al. Dual-color metal-induced and förster resonance energy transfer for cell nanoscopy. Mol Biol Cell N/A:N/A (2018). PubMed: 29444956
  • Atkinson SJ  et al. The ß3-integrin endothelial adhesome regulates microtubule-dependent cell migration. EMBO Rep 19:N/A (2018). PubMed: 29794156
  • Saxena M  et al. EGFR and HER2 activate rigidity sensing only on rigid matrices. Nat Mater 16:775-781 (2017). PubMed: 28459445
  • Jessen TN & Jessen JR VANGL2 interacts with integrin av to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix. Exp Cell Res 361:265-276 (2017). WB ; Human . PubMed: 29097183
  • Tong MH  et al. Preferential sensing and response to microenvironment stiffness of human dermal fibroblast cultured on protein micropatterns fabricated by 3D multiphoton biofabrication. Sci Rep 7:12402 (2017). ICC/IF ; Human . PubMed: 28963517
  • Fuhrmann A  et al. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophys J 112:736-745 (2017). PubMed: 28256233
  • Cui S  et al. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways. Oncotarget 8:21674-21691 (2017). PubMed: 28423510
  • Amin EM  et al. The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. Sci Signal 10:N/A (2017). PubMed: 28928239
  • Kittur H  et al. Probing Cell Adhesion Profiles with a Microscale Adhesive Choice Assay. Biophys J 113:1858-1867 (2017). PubMed: 29045879
  • Fantauzzo KA & Soriano P Generation of an immortalized mouse embryonic palatal mesenchyme cell line. PLoS One 12:e0179078 (2017). ICC/IF ; Mouse . PubMed: 28582446
  • Hanga MP  et al. Expansion of bone marrow-derived human mesenchymal stem/stromal cells (hMSCs) using a two-phase liquid/liquid system. J Chem Technol Biotechnol 92:1577-1589 (2017). ICC/IF ; Human . PubMed: 28706339
  • Sero JE & Bakal C Multiparametric Analysis of Cell Shape Demonstrates that ß-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Syst 4:84-96.e6 (2017). PubMed: 28065575
  • Haffner MC  et al. AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. Nat Commun 8:142 (2017). PubMed: 28747635
  • Rashid M  et al. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development 144:4002-4014 (2017). PubMed: 28935710
  • González-Tarragó V  et al. Binding of ZO-1 to a5ß1 integrins regulates the mechanical properties of a5ß1-fibronectin links. Mol Biol Cell 28:1847-1852 (2017). PubMed: 28251923
  • Mekhdjian AH  et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell 28:1467-1488 (2017). PubMed: 28381423
  • Wei X  et al. Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. J Cell Biol 216:1455-1471 (2017). PubMed: 28408404
  • Kawano S  et al. Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. Biol Open 6:1644-1653 (2017). PubMed: 28970230
  • Taylor KM  et al. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Biochem J 473:2531-44 (2016). PubMed: 27274087
  • Courtheoux T  et al. Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase. Nat Commun 7:12810 (2016). ICC/IF ; Human . PubMed: 27641145
  • Chen NP  et al. Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci U S A 113:990-5 (2016). PubMed: 26747605
  • Izumi D  et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin ß1 clustering and invasiveness in gastric cancer. Int J Cancer 138:1207-19 (2016). ICC/IF ; Human . PubMed: 26414794
  • Yariswamy M  et al. Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction. J Biol Chem 291:19425-36 (2016). PubMed: 27466370
  • Harrington KM & Clevenger CV Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. J Biol Chem 291:21388-21406 (2016). PubMed: 27489110
  • Ross-Adams H  et al. HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer. Oncotarget 7:74734-74746 (2016). WB ; Human . PubMed: 27732966
  • Tsai CS  et al. Thrombomodulin regulates monocye differentiation via PKCd and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep 6:38421 (2016). WB ; Human . PubMed: 27910925
  • Chaudhuri O  et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat Mater 15:326-34 (2016). PubMed: 26618884
  • Lee J  et al. Matrix directed adipogenesis and neurogenesis of mesenchymal stem cells derived from adipose tissue and bone marrow. Acta Biomater 42:46-55 (2016). PubMed: 27375285
  • Gan Z  et al. Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration. Cell Syst 3:252-263.e8 (2016). PubMed: 27667364
  • Holle AW  et al. High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation. Integr Biol (Camb) 8:1049-1058 (2016). PubMed: 27723854
  • Xing Q  et al. Nitric oxide regulates cell behavior on an interactive cell-derived extracellular matrix scaffold. J Biomed Mater Res A 103:3807-14 (2015). ICC/IF ; Human . PubMed: 26074441
  • Broughton KM & Russell B Cardiomyocyte subdomain contractility arising from microenvironmental stiffness and topography. Biomech Model Mechanobiol 14:589-602 (2015). ICC/IF ; Rat . PubMed: 25273278
  • Ellison TS  et al. Suppression of ß3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech 8:1105-19 (2015). WB, ICC/IF ; Mouse . PubMed: 26159543
  • Hamill KJ  et al. Alpha actinin-1 regulates cell-matrix adhesion organization in keratinocytes: consequences for skin cell motility. J Invest Dermatol 135:1043-52 (2015). PubMed: 25431851
  • Greiner AM  et al. Temporal responses of human endothelial and smooth muscle cells exposed to uniaxial cyclic tensile strain. Exp Biol Med (Maywood) 240:1298-309 (2015). ICC/IF ; Human . PubMed: 25687334
  • Chaudhuri O  et al. Substrate stress relaxation regulates cell spreading. Nat Commun 6:6364 (2015). IHC (PFA fixed) . PubMed: 25695512
  • Fuhrmann A & Engler AJ The cytoskeleton regulates cell attachment strength. Biophys J 109:57-65 (2015). WB, ICC/IF . PubMed: 26153702
  • Fuhrmann A  et al. Cation type specific cell remodeling regulates attachment strength. PLoS One 9:e102424 (2014). ICC/IF ; Mouse . PubMed: 25014042
  • Kligys K  et al. Laminin-332 and a3ß1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin. Am J Respir Cell Mol Biol 49:731-40 (2013). Human . PubMed: 23590307
  • Eisenberg JL  et al. Plectin-containing, centrally localized focal adhesions exert traction forces in primary lung epithelial cells. J Cell Sci 126:3746-55 (2013). Human . PubMed: 23750011
  • Chen DL  et al. Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer. J Transl Med 11:277 (2013). IHC-P ; Human . PubMed: 24180516
  • Woskowicz AM  et al. MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem 288:35126-37 (2013). ICC/IF ; Human . PubMed: 24165131
  • van Leeuwen IM  et al. Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2. Mol Cancer Ther 12:471-80 (2013). Human . PubMed: 23416275
  • Holle AW  et al. In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells 31:2467-77 (2013). ICC/IF ; Human . PubMed: 23897765
  • Rausch S  et al. Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration. Biointerphases 8:32 (2013). ICC/IF . PubMed: 24706149
  • Tomkiewicz C  et al. The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway. Oncogene : (2012). PubMed: 22665056
  • Sureshbabu A  et al. IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. J Cell Sci 125:1693-705 (2012). ICC/IF ; Human . PubMed: 22328518
  • Pescatore LA  et al. Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation. J Biol Chem 287:29290-300 (2012). ICC/IF ; Rabbit . PubMed: 22773830
  • Veith C  et al. Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension. Am J Pathol 181:1621-33 (2012). WB, IHC-P, ICC/IF ; Mouse, Human . PubMed: 22959909
  • Lawson C  et al. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol 196:223-32 (2012). WB, ICC/IF ; Human, Mouse . PubMed: 22270917
  • Patel A & Dash PR Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation. Eur J Cell Biol 91:171-9 (2012). ICC/IF . PubMed: 22284833
  • Chen TT  et al. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188:595-609 (2010). ICC/IF ; Human . PubMed: 20176926
  • To WS & Midwood KS Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis. Matrix Biol 29:573-85 (2010). ICC/IF ; Human . PubMed: 20708078
  • Curtis MW  et al. Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdevices 12:1073-85 (2010). ICC/IF ; Rat . PubMed: 20668947
  • Zhu HY  et al. Epithelial microfilament regulators show regional distribution in mouse conjunctiva. Mol Vis 16:2215-24 (2010). WB, IHC-Fr ; Mouse . PubMed: 21151337
  • Goldyn AM  et al. Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J Cell Sci 122:3644-51 (2009). ICC/IF ; Mouse . PubMed: 19812308

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