Anti-Paxillin antibody [Y113] (ab32084)

Rabbit recombinant monoclonal Paxillin antibody [Y113]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Cow, Dog, Human. Cited in 63 publication(s).

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ab32084 has been referenced in 63 publications.

  • Charrier EE  et al. Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation. Nat Commun 9:449 (2018). PubMed: 29386514
  • Lai H  et al. FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer. J Exp Clin Cancer Res 37:32 (2018). PubMed: 29458390
  • Ng PK  et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell 33:450-462.e10 (2018). PubMed: 29533785
  • Mohagheghian E  et al. Quantifying compressive forces between living cell layers and within tissues using elastic round microgels. Nat Commun 9:1878 (2018). PubMed: 29760452
  • Gonzalez-Molina J  et al. Extracellular fluid viscosity enhances liver cancer cell mechanosensing and migration. Biomaterials 177:113-124 (2018). WB . PubMed: 29886384
  • Zhang YL  et al. Integrin a9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling. J Immunol Res 2018:4602570 (2018). PubMed: 29951557
  • Shen J  et al. Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer. J Exp Clin Cancer Res 37:175 (2018). PubMed: 30055645
  • Chizhik AM  et al. Dual-color metal-induced and förster resonance energy transfer for cell nanoscopy. Mol Biol Cell N/A:N/A (2018). PubMed: 29444956
  • Atkinson SJ  et al. The ß3-integrin endothelial adhesome regulates microtubule-dependent cell migration. EMBO Rep 19:N/A (2018). PubMed: 29794156
  • McKenzie AJ  et al. The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation. Sci Rep 8:7228 (2018). PubMed: 29740072
  • Wu KH  et al. The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter. J Food Drug Anal 26:221-231 (2018). WB ; Human . PubMed: 29389559
  • Tong MH  et al. Preferential sensing and response to microenvironment stiffness of human dermal fibroblast cultured on protein micropatterns fabricated by 3D multiphoton biofabrication. Sci Rep 7:12402 (2017). ICC/IF ; Human . PubMed: 28963517
  • Fuhrmann A  et al. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophys J 112:736-745 (2017). PubMed: 28256233
  • Cui S  et al. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways. Oncotarget 8:21674-21691 (2017). PubMed: 28423510
  • Saxena M  et al. EGFR and HER2 activate rigidity sensing only on rigid matrices. Nat Mater 16:775-781 (2017). PubMed: 28459445
  • Jessen TN & Jessen JR VANGL2 interacts with integrin av to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix. Exp Cell Res 361:265-276 (2017). WB ; Human . PubMed: 29097183
  • Fantauzzo KA & Soriano P Generation of an immortalized mouse embryonic palatal mesenchyme cell line. PLoS One 12:e0179078 (2017). ICC/IF ; Mouse . PubMed: 28582446
  • Hanga MP  et al. Expansion of bone marrow-derived human mesenchymal stem/stromal cells (hMSCs) using a two-phase liquid/liquid system. J Chem Technol Biotechnol 92:1577-1589 (2017). ICC/IF ; Human . PubMed: 28706339
  • Sero JE & Bakal C Multiparametric Analysis of Cell Shape Demonstrates that ß-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Syst 4:84-96.e6 (2017). PubMed: 28065575
  • Haffner MC  et al. AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. Nat Commun 8:142 (2017). PubMed: 28747635
  • Rashid M  et al. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development 144:4002-4014 (2017). PubMed: 28935710
  • González-Tarragó V  et al. Binding of ZO-1 to a5ß1 integrins regulates the mechanical properties of a5ß1-fibronectin links. Mol Biol Cell 28:1847-1852 (2017). PubMed: 28251923
  • Mekhdjian AH  et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell 28:1467-1488 (2017). PubMed: 28381423
  • Wei X  et al. Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. J Cell Biol 216:1455-1471 (2017). PubMed: 28408404
  • Kawano S  et al. Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. Biol Open 6:1644-1653 (2017). PubMed: 28970230
  • Taylor KM  et al. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Biochem J 473:2531-44 (2016). PubMed: 27274087
  • Courtheoux T  et al. Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase. Nat Commun 7:12810 (2016). ICC/IF ; Human . PubMed: 27641145
  • Chen NP  et al. Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci U S A 113:990-5 (2016). PubMed: 26747605
  • Izumi D  et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin ß1 clustering and invasiveness in gastric cancer. Int J Cancer 138:1207-19 (2016). ICC/IF ; Human . PubMed: 26414794
  • Yariswamy M  et al. Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction. J Biol Chem 291:19425-36 (2016). PubMed: 27466370
  • Harrington KM & Clevenger CV Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. J Biol Chem 291:21388-21406 (2016). PubMed: 27489110
  • Ross-Adams H  et al. HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer. Oncotarget 7:74734-74746 (2016). WB ; Human . PubMed: 27732966
  • Tsai CS  et al. Thrombomodulin regulates monocye differentiation via PKCd and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep 6:38421 (2016). WB ; Human . PubMed: 27910925
  • Chaudhuri O  et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat Mater 15:326-34 (2016). PubMed: 26618884
  • Lee J  et al. Matrix directed adipogenesis and neurogenesis of mesenchymal stem cells derived from adipose tissue and bone marrow. Acta Biomater 42:46-55 (2016). PubMed: 27375285
  • Gan Z  et al. Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration. Cell Syst 3:252-263.e8 (2016). PubMed: 27667364
  • Holle AW  et al. High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation. Integr Biol (Camb) 8:1049-1058 (2016). PubMed: 27723854
  • Xing Q  et al. Nitric oxide regulates cell behavior on an interactive cell-derived extracellular matrix scaffold. J Biomed Mater Res A 103:3807-14 (2015). ICC/IF ; Human . PubMed: 26074441
  • Broughton KM & Russell B Cardiomyocyte subdomain contractility arising from microenvironmental stiffness and topography. Biomech Model Mechanobiol 14:589-602 (2015). ICC/IF ; Rat . PubMed: 25273278
  • Ellison TS  et al. Suppression of ß3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech 8:1105-19 (2015). WB, ICC/IF ; Mouse . PubMed: 26159543
  • Hamill KJ  et al. Alpha actinin-1 regulates cell-matrix adhesion organization in keratinocytes: consequences for skin cell motility. J Invest Dermatol 135:1043-52 (2015). PubMed: 25431851
  • Greiner AM  et al. Temporal responses of human endothelial and smooth muscle cells exposed to uniaxial cyclic tensile strain. Exp Biol Med (Maywood) 240:1298-309 (2015). ICC/IF ; Human . PubMed: 25687334
  • Chaudhuri O  et al. Substrate stress relaxation regulates cell spreading. Nat Commun 6:6364 (2015). IHC (PFA fixed) . PubMed: 25695512
  • Fuhrmann A & Engler AJ The cytoskeleton regulates cell attachment strength. Biophys J 109:57-65 (2015). WB, ICC/IF . PubMed: 26153702
  • Fuhrmann A  et al. Cation type specific cell remodeling regulates attachment strength. PLoS One 9:e102424 (2014). ICC/IF ; Mouse . PubMed: 25014042
  • Kligys K  et al. Laminin-332 and a3ß1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin. Am J Respir Cell Mol Biol 49:731-40 (2013). Human . PubMed: 23590307
  • Eisenberg JL  et al. Plectin-containing, centrally localized focal adhesions exert traction forces in primary lung epithelial cells. J Cell Sci 126:3746-55 (2013). Human . PubMed: 23750011
  • Chen DL  et al. Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer. J Transl Med 11:277 (2013). IHC-P ; Human . PubMed: 24180516
  • Woskowicz AM  et al. MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem 288:35126-37 (2013). ICC/IF ; Human . PubMed: 24165131
  • van Leeuwen IM  et al. Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2. Mol Cancer Ther 12:471-80 (2013). Human . PubMed: 23416275
  • Holle AW  et al. In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells 31:2467-77 (2013). ICC/IF ; Human . PubMed: 23897765
  • Rausch S  et al. Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration. Biointerphases 8:32 (2013). ICC/IF . PubMed: 24706149
  • Tomkiewicz C  et al. The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway. Oncogene : (2012). PubMed: 22665056
  • Sureshbabu A  et al. IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. J Cell Sci 125:1693-705 (2012). ICC/IF ; Human . PubMed: 22328518
  • Pescatore LA  et al. Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation. J Biol Chem 287:29290-300 (2012). ICC/IF ; Rabbit . PubMed: 22773830
  • Veith C  et al. Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension. Am J Pathol 181:1621-33 (2012). WB, IHC-P, ICC/IF ; Mouse, Human . PubMed: 22959909
  • Lawson C  et al. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol 196:223-32 (2012). WB, ICC/IF ; Human, Mouse . PubMed: 22270917
  • Patel A & Dash PR Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation. Eur J Cell Biol 91:171-9 (2012). ICC/IF . PubMed: 22284833
  • Chen TT  et al. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188:595-609 (2010). ICC/IF ; Human . PubMed: 20176926
  • To WS & Midwood KS Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis. Matrix Biol 29:573-85 (2010). ICC/IF ; Human . PubMed: 20708078
  • Curtis MW  et al. Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdevices 12:1073-85 (2010). ICC/IF ; Rat . PubMed: 20668947
  • Zhu HY  et al. Epithelial microfilament regulators show regional distribution in mouse conjunctiva. Mol Vis 16:2215-24 (2010). WB, IHC-Fr ; Mouse . PubMed: 21151337
  • Goldyn AM  et al. Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J Cell Sci 122:3644-51 (2009). ICC/IF ; Mouse . PubMed: 19812308


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