Overview

  • Product name

    Paxilline, Ca2+-activated K+channel blocker
  • Description

    Potent high-conductance Ca2+-activated K+channel blocker
  • Biological description

    Potent high-conductance Ca2+-activated K+channel blocker (Ki = 2 nM, α-subunit BKCa) Inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM). Shows anticonvulsant effects in vivo.
  • Purity

    > 98%
  • CAS Number

    57186-25-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
  • Molecular weight

    435.60
  • Molecular formula

    C27H33NO4
  • PubChem identifier

    105008
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
  • Source

    Penicillium paxilli

  • Research areas

References

This product has been referenced in:

  • Sheehan JJ  et al. Anticonvulsant effects of the BK-channel antagonist paxilline. Epilepsia 50:711-20 (2009). Read more (PubMed: 19054419) »
  • Bilmen JG  et al. The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline. Arch Biochem Biophys 406:55-64 (2002). Read more (PubMed: 12234490) »
  • Sanchez M & McManus OB Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35:963-8 (1996). Read more (PubMed: 8938726) »

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