Validated using a knockout cell line

Recombinant Anti-PBR antibody [EPR5384] (ab109497)

Knockout Tested Rabbit recombinant monoclonal PBR antibody [EPR5384]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Human. Cited in 33 publication(s).

Publishing research using ab109497? Please let us know so that we can cite the reference in this datasheet.

ab109497 has been referenced in 41 publications.

  • Thau-Zuchman O  et al. Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury. J Neurotrauma 36:25-42 (2019). PubMed: 29768974
  • Tournier BB  et al. TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease. Neurobiol Dis 121:95-105 (2019). PubMed: 30261283
  • Fan J  et al. Nr5a1-Cre-mediated Tspo conditional knockout mice with low growth rate and prediabetes symptoms - A mouse model of stress diabetes. Biochim Biophys Acta Mol Basis Dis 1865:56-62 (2019). PubMed: 30343141
  • Zou T  et al. Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents. Nat Commun 10:1205 (2019). PubMed: 30872578
  • Lin YM  et al. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int 2019:3102414 (2019). PubMed: 30984779
  • Betlazar C  et al. Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain. Int J Mol Sci 19:N/A (2018). PubMed: 30208620
  • Hosomi S  et al. Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice. Neuroimage Clin 20:946-954 (2018). PubMed: 30312938
  • Fan J  et al. CRISPR/Cas9?Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells. Endocrinology 159:1130-1146 (2018). PubMed: 29300865
  • Li J  et al. The Protection of Midazolam Against Immune Mediated Liver Injury Induced by Lipopolysaccharide and Galactosamine in Mice. Front Pharmacol 9:1528 (2018). PubMed: 30670973
  • Chung SJ  et al. In vivo imaging of activated macrophages by 18F-FEDAC, a TSPO targeting PET ligand, in the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs). Biochem Biophys Res Commun 506:216-222 (2018). PubMed: 30343885
  • Thai PN  et al. Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Sci Rep 8:16213 (2018). PubMed: 30385779
  • Lanfranca MP  et al. Tracking Macrophage Infiltration in a Mouse Model of Pancreatic Cancer with the Positron Emission Tomography Tracer [11C]PBR28. J Surg Res 232:570-577 (2018). PubMed: 30463776
  • Biswas L  et al. TSPO Ligands Promote Cholesterol Efflux and Suppress Oxidative Stress and Inflammation in Choroidal Endothelial Cells. Int J Mol Sci 19:N/A (2018). PubMed: 30477223
  • Chaney A  et al. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1?e9 transgenic mouse model of Alzheimer's disease. J Neurochem 144:318-335 (2018). IHC-Fr ; Mouse . PubMed: 29124761
  • Pantaleão L  et al. Connections of annexin A1 and translocator protein-18?kDa on toll like receptor stimulated BV-2 cells. Exp Cell Res 367:282-290 (2018). PubMed: 29649428
  • Simmons DA  et al. TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31. Hum Mol Genet 27:2893-2912 (2018). PubMed: 29860333
  • Gatliff J  et al. A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling. Cell Death Dis 8:e2896 (2017). WB ; Mouse . PubMed: 28640253
  • Biswas L  et al. Retinal pigment epithelium cholesterol efflux mediated by the 18?kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration. Hum Mol Genet 26:4327-4339 (2017). PubMed: 28973423
  • Song D  et al. Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. Mol Vis 23:210-218 (2017). IHC-Fr ; Mouse . PubMed: 28442885
  • Li HD  et al. A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury. J Neuroinflammation 14:151 (2017). PubMed: 28754131
  • Hescot S  et al. Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches. Oncotarget 8:109924-109940 (2017). PubMed: 29299119
  • Yang J  et al. Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and64CuCl2. Sci Rep 7:8298 (2017). PubMed: 28811616
  • James ML  et al. [18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease. Theranostics 7:1422-1436 (2017). IHC-FrFl ; Mouse . PubMed: 28529627
  • Barron AM  et al. Assessment of neuroinflammation in a mouse model of obesity and ß-amyloidosis using PET. J Neuroinflammation 13:221 (2016). IHC-Fr ; Mouse . PubMed: 27578213
  • Wang H  et al. Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile. PLoS One 11:e0167307 (2016). WB, IHC ; Mouse . PubMed: 27907096
  • Loth MK  et al. TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiol Dis 85:174-186 (2016). PubMed: 26545928
  • Lee JW  et al. Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes. Exp Neurobiol 25:262-268 (2016). PubMed: 27790060
  • Selvaraj V  et al. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal. Mol Endocrinol 29:490-501 (2015). PubMed: 25730708
  • Fan J  et al. Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci U S A 112:7261-6 (2015). PubMed: 26039990
  • Zhao L  et al. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7:1179-97 (2015). IHC . PubMed: 26139610
  • Zhang S  et al. Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer. Acta Biomater 28:160-170 (2015). PubMed: 26432436
  • Tóth M  et al. Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking. Brain Struct Funct N/A:N/A (2015). PubMed: 25601153
  • Banati RB  et al. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun 5:5452 (2014). WB, IHC ; Mouse . PubMed: 25406832
  • Karlstetter M  et al. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation 11:3 (2014). WB, ICC/IF ; Mouse . PubMed: 24397957
  • Wang M  et al. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci 34:3793-806 (2014). Mouse . PubMed: 24599476
  • Buckman LB  et al. Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte 3:215-20 (2014). ICC/IF ; Human . PubMed: 25068089
  • Tu LN  et al. Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J Biol Chem 289:27444-54 (2014). WB, IHC ; Mouse . PubMed: 24936060
  • Gatliff J  et al. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 10:2279-96 (2014). PubMed: 25470454
  • Faccenda D  et al. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ 20:686-97 (2013). WB ; Mouse, Human . PubMed: 23348567
  • Morohaku K  et al. Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues. PLoS One 8:e74509 (2013). WB, ICC/IF ; Mouse . PubMed: 24040265
  • Thompson MM  et al. Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One 8:e79980 (2013). IHC-P ; Mouse . PubMed: 24260329

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