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    pbx1prl-antibody-ab154285.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Developmental Families Other
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Anti-PBX1/PRL antibody (ab154285)

  • Datasheet
  • SDS
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Western blot - Anti-PBX1/PRL antibody (ab154285)

    Key features and details

    • Rabbit polyclonal to PBX1/PRL
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-PBX1/PRL antibody
      See all PBX1/PRL primary antibodies
    • Description

      Rabbit polyclonal to PBX1/PRL
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      Recombinant fragment corresponding to Human PBX1/PRL aa 1-311.

    • Positive control

      • A431 whole cell lysate
    • General notes

      Previously labelled as PBX1. 

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • Storage buffer

      pH: 7.00
      Preservative: 0.01% Thimerosal (merthiolate)
      Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine)
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Developmental Families
      • Other
      • Stem Cells
      • Hematopoietic Progenitors
      • Hematopoietic Stem Cells
      • HSC markers

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • A-431 whole cell lysate (ab7909)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab154285 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    All applications
    Mouse
    Rat
    Chicken
    Cow
    Xenopus laevis
    Xenopus tropicalis
    Application Abreviews Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 47 kDa.
    Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 47 kDa.

    Target

    • Function

      Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.
    • Tissue specificity

      Expressed in all tissues except in cells of the B and T lineage.
    • Involvement in disease

      Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
    • Sequence similarities

      Belongs to the TALE/PBX homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P40424 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 395505 Chicken
      • Entrez Gene: 540688 Cow
      • Entrez Gene: 5087 Human
      • Entrez Gene: 18514 Mouse
      • Entrez Gene: 304947 Rat
      • Entrez Gene: 399184 Xenopus laevis
      • Omim: 176310 Human
      • SwissProt: P40424 Human
      • SwissProt: P41778 Mouse
      • SwissProt: Q8QGC4 Xenopus laevis
      • SwissProt: B4F6V6 Xenopus tropicalis
      • Unigene: 557097 Human
      • Unigene: 43358 Mouse
      • Unigene: 440114 Mouse
      • Unigene: 205189 Rat
      • Unigene: 77419 Xenopus laevis
      see all
    • Alternative names

      • DKFZp686B09108 antibody
      • Homeo box protein PBX1 antibody
      • Homeo box protein PRL antibody
      • Homeobox protein PBX 1 antibody
      • Homeobox protein PBX1 antibody
      • Homeobox protein PRL antibody
      • MGC126627 antibody
      • PBX 1 antibody
      • Pbx1 antibody
      • PBX1_HUMAN antibody
      • Pre B cell leukemia homeobox 1 antibody
      • Pre B cell leukemia transcription factor 1 antibody
      • Pre-B-cell leukemia transcription factor 1 antibody
      • PRL antibody
      see all

    Images

    • Western blot - Anti-PBX1/PRL antibody (ab154285)
      Western blot - Anti-PBX1/PRL antibody (ab154285)
      Anti-PBX1/PRL antibody (ab154285) at 1/1000 dilution + A431 whole cell
      lysate at 30 µg

      Predicted band size: 47 kDa



      10% SDS PAGE

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab154285? Please let us know so that we can cite the reference in this datasheet.

    ab154285 has been referenced in 1 publication.

    • Platais C  et al. Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes. BMC Cancer 18:723 (2018). PubMed: 29980182

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