Anti-PC1/3 antibody (ab154246)
- Datasheet
- References
- Protocols
Overview
-
Product name
Anti-PC1/3 antibody
See all PC1/3 primary antibodies -
Description
Rabbit polyclonal to PC1/3 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Zebrafish
-
Immunogen
Recombinant fragment, corresponding to a region within amino acids 93-390 of Human PC1/3 (Uniprot ID P29120).
-
Positive control
- HepG2 and HCT116 whole cell lysates; Cal27 xenograft tissue.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
Our Abpromise guarantee covers the use of ab154246 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 84 kDa. | |
| IHC-P | 1/100 - 1/1000. |
Target
-
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. -
Involvement in disease
Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones. -
Sequence similarities
Belongs to the peptidase S8 family. Furin subfamily. -
Cellular localization
Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules. - Information by UniProt
-
Database links
- Entrez Gene: 281967 Cow
- Entrez Gene: 5122 Human
- Entrez Gene: 18548 Mouse
- Entrez Gene: 25204 Rat
- Entrez Gene: 100005716 Zebrafish
- Omim: 162150 Human
- SwissProt: Q9GLR1 Cow
- SwissProt: P29120 Human
see all -
Alternative names
- BDP antibody
- NEC 1 antibody
- NEC1 antibody
see all
Images
-
Western blot - Anti-PC1/3 antibody (ab154246)Anti-PC1/3 antibody (ab154246) at 1/500 dilution + HCT116 whole cell lysate at 30 µg
Predicted band size: 84 kDa
7.5% SDS PAGE -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PC1/3 antibody (ab154246)Immunohistochemical analysis of paraffin embedded Cal27 xenograft tissue labeling PC1/3 with ab154246 at 1/500.
References
ab154246 has not yet been referenced specifically in any publications.
