Overview

  • Product name

  • Description

    Rabbit polyclonal to PCCB
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 87-117 of Human PCCB.

  • Positive control

    • Jurkat cell line lysate; Jurkat cells

Properties

Applications

Our Abpromise guarantee covers the use of ab135720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 58 kDa.
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

Target

  • Pathway

    Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.
  • Involvement in disease

    Defects in PCCB are the cause of propionic acidemia type II (PA-2) [MIM:606054]. PA-2 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein.
  • Sequence similarities

    Belongs to the AccD/PCCB family.
    Contains 1 carboxyltransferase domain.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp451E113 antibody
    • PCCase subunit beta antibody
    • pccB antibody
    • PCCB_HUMAN antibody
    • pccBC Complementation group antibody
    • Propanoyl CoA:carbon dioxide ligase subunit beta antibody
    • Propanoyl-CoA:carbon dioxide ligase subunit beta antibody
    • Propionyl CoA carboxylase beta chain, mitochondrial antibody
    • propionyl Coenzyme A carboxylase, beta polypeptide antibody
    • Propionyl-CoA carboxylase , beta subunit antibody
    • Propionyl-CoA carboxylase beta chain, mitochondrial antibody
    • R74805 antibody
    see all

Images

  • Anti-PCCB antibody (ab135720) at 1/100 dilution + Jurkat cell line lysate at 35 µg

    Predicted band size: 58 kDa

  • Flow cytometry analysis of Jurkat cells labelling PCCB with ab135720 at 1/10 dilution (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

References

ab135720 has not yet been referenced specifically in any publications.

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