Overview

  • Product name

    PD 128907 hydrochloride, D3 receptor agonist
  • Description

    Potent, selective D3 receptor agonist
  • Biological description

    Potent, selective D3 receptor agonist (Ki = 2.3 nM). Inhibits dopamine release. Reduces GABAAR current in acutely dissociated NAc neurons. Shows locomotor-inhibitory effects in vivo. Centrally active.
  • Purity

    > 99%
  • CAS Number

    112960-16-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4aR,10bR)-4-Propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride
  • Molecular weight

    285.77
  • Molecular formula

    C14H19NO3.HCl
  • PubChem identifier

    11957668
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Maina FK & Mathews TA A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem Neurosci 1:450-462 (2010). Read more (PubMed: 20567609) »
  • Chen G  et al. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci 26:2513-21 (2006). Read more (PubMed: 16510729) »
  • McNamara RK  et al. C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice. Neuroscience 143:141-53 (2006). Read more (PubMed: 16938406) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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