Key features and details
- Potent, selective calpain inhibitor. Cell-permeable.
- CAS Number: 179528-45-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product namePD 150606, Calpain inhibitor
DescriptionPotent, selective calpain inhibitor. Cell-permeable.
Potent, selective and cell-permeable Ca2+-dependent calpain inhibitor (Ki values are 210 and 370 nM for calpain-1 and calpain-2 respectively). Non-competitive and non-peptide. Irreversibly inhibits ICa through AMPA receptors. Anti-ischemic effects in vivo.
Chemical name(Z)-3-(4-Iodophenyl)-2-sulfanylprop-2-enoic acid
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141464 has been referenced in 3 publications.
- Song Z et al. Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus. Neuropharmacology 174:108175 (2020). PubMed: 32492450
- Metwally E et al. Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at the Drosophila Neuromuscular Junction. J Neurosci 39:2776-2791 (2019). PubMed: 30705102
- Tan WJ et al. Calpain 1 regulates TGF-ß1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway. Am J Transl Res 9:1402-1409 (2017). PubMed: 28386365