Overview

  • Product name

    PD 151746, Calpain inhibitor
  • Description

    Cell permeable, selective, non-peptidic calpain inhibitor
  • Biological description

    Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.
  • Purity

    > 96%
  • CAS Number

    179461-52-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid
  • Molecular weight

    237.25
  • Molecular formula

    C11H8FNO2S
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Unstable; make up solutions fresh and use immediately.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S
  • Source

    Synthetic

References

This product has been referenced in:

  • Fujita H  et al. Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. Arch Biochem Biophys 516:121-7 (2011). Read more (PubMed: 22005393) »
  • Meier M  et al. Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling. J Endocrinol 193:45-51 (2007). Read more (PubMed: 17400802) »
  • Jost MM  et al. The beta3-adrenergic agonist CL316,243 inhibits insulin signaling but not glucose uptake in primary human adipocytes. Exp Clin Endocrinol Diabetes 113:418-22 (2005). Read more (PubMed: 16151974) »

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