Overview

  • Product name

    PD 153035 hydrochloride, EGFR tyrosine kinase inhibitor
  • Description

    Highly potent, selective EGFR tyrosine kinase inhibitor
  • Biological description

    Highly potent, selective EGFR tyrosine kinase inhibitor (Ki value = 6 pM). Active in vitro and in vivo.
  • Purity

    > 95%
  • CAS Number

    153436-54-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bridges AJ  et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem 39:267-76 (1996). Read more (PubMed: 8568816) »
  • Kunkel MW  et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs 13:295-302 (1996). Read more (PubMed: 8824347) »
  • Fry DW  et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265:1093-5 (1994). Read more (PubMed: 8066447) »

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