PD 166866, FGFR1 tyrosine kinase inhibitor (ab229182)

Overview

  • Product name

    PD 166866, FGFR1 tyrosine kinase inhibitor
  • Description

    Potent, highly selective inhibitor of FGFR1 tyrosine kinase.
  • Biological description

    Potent, highly selective inhibitor of FGFR1 tyrosine kinase. Inhibits the autophosphorylation of FGFR1 (IC50 = 52.4 ± 0.1 nM) with no effect on c-Src, PDGF receptor β, EGFR or insulin receptor tyrosine kinases, MAPK, PKC and CDK4 at concentrations as high as 50 μM.

  • Purity

    > 99%
  • CAS Number

    192705-79-6

Properties

  • Chemical name

    N-[2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
  • Molecular weight

    396.44
  • Molecular formula

    C20H24N6O3
  • PubChem identifier

    5328127
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Chen Y  et al. FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell. Biochem Biophys Res Commun : (2016). Read more (PubMed: 26993162) »
  • Risuleo G  et al. The synthetic inhibitor of fibroblast growth factor receptor PD166866 controls negatively the growth of tumor cells in culture. J Exp Clin Cancer Res 28:151 (2009). Read more (PubMed: 20003343) »
  • Panek RL  et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther 286:569-77 (1998). Read more (PubMed: 9655904) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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