Overview

  • Product name

    PD 168393, EGFR inhibitor
  • Description

    Potent, irreversible, cell-permeable and selective EGFR inhibitor
  • Biological description

    Potent, irreversible, cell-permeable, selective EGFR inhibitor (IC50 values are 0.7, 0.08, 5.7, 12 and 15 nM for EGF receptor tyrosine kinase, erbB1, erbB2, erbB4 and SK-BR-3, respectively). Binds to the catalytic domain. Inhibits cancer cell growth. Blocks reactive astrogliosis and shows neuroprotective effects in vivo.
  • Purity

    > 98%
  • CAS Number

    194423-15-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide
  • Molecular weight

    369.22
  • Molecular formula

    C17H13BrN4O
  • PubChem identifier

    4708
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br
  • Source

    Synthetic

References

This product has been referenced in:

  • Li ZW  et al. Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury. J Neuroinflammation 11:71 (2014). Read more (PubMed: 24708754) »
  • Pu YS  et al. Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells. Biochem Pharmacol 71:751-60 (2006). Read more (PubMed: 16413505) »
  • Delivoria-Papadopoulou M & Malaeb S Effect of concurrent administration of apoptotic inhibitors and hypothermia on post hypoxic cerebral injury in the newborn. Hell J Nucl Med 17 Suppl 1:24-5 (0). Read more (PubMed: 24392464) »

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