Overview

  • Product name

    PD-184161, MEK1/2 inhibitor
  • Description

    Potent, selective MEK1/2 inhibitor
  • Biological description

    Potent, selective MEK1/2 inhibitor (IC50 values are 10 to 100 nM). Inhibits ERK1/2 activation more potently than PD-098059. Induces apoptosis. Shows neuroprotective, antiproliferative and and antitumor effects in vivo.
  • CAS Number

    212631-67-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Gladbach A  et al. ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. J Neural Transm 121:543-7 (2014). Read more (PubMed: 24337667) »
  • Mazharian A  et al. Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation. Exp Hematol 37:1238-1249.e5 (2009). Read more (PubMed: 19619605) »
  • Klein PJ  et al. The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. Neoplasia 8:1-8 (2006). Read more (PubMed: 16533420) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143847.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up