PD-1/PD-L1 Inhibitor 3, A macrocyclic inhibitor (ab231310)

Overview

  • Product name

    PD-1/PD-L1 Inhibitor 3, A macrocyclic inhibitor
  • Description

    A macrocyclic inhibitor
  • Alternative names

    • Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3
  • Biological description

    PD-1/PD-L1 Inhibitor is a macrocyclic inhibitor of PD-1/PD-L1 interaction with an IC50 of 5.6 nM. In vitro ab231310 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity.

  • CAS Number

    1629654-95-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1852.20
  • Molecular formula

    C89H126N24O18S
  • Sequence

    FANPHLGWSWXXRXG (Modifications: N(Me)Nle, N(Me)Nle, C(1))
  • PubChem identifier

    129896719
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    100 mg/mL (53.99 mM) in water

  • Source

    Synthetic

References

This product has been referenced in:

  • Khunger M  et al. Safety and Efficacy of PD-1/PD-L1 Inhibitors in Treatment-Naive and Chemotherapy-Refractory Patients With Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Clin Lung Cancer N/A:N/A (2018). Read more (PubMed: 29433902) »

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