Key features and details
- Rabbit polyclonal to PD-L2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PD-L2 antibody
See all PD-L2 primary antibodies
DescriptionRabbit polyclonal to PD-L2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide within Human PD-L2 (internal sequence). The exact sequence is proprietary.
Database link: Q9BQ51
- Human thyroid cancer tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab200377 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionInvolved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Tissue specificityHighly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localizationSecreted; Cell membrane and Endomembrane system.
- Information by UniProt
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ab200377 has been referenced in 2 publications.
- Zhang X et al. Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma. BMC Cancer 19:360 (2019). PubMed: 30992011
- Guo PD et al. Clinicopathological analysis of PD-L2 expression in colorectal cancer. Onco Targets Ther 11:7635-7642 (2018). PubMed: 30464512