Overview

  • Product name

  • Description

    Rabbit polyclonal to PD-L2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PD-L2 (internal sequence). The exact sequence is proprietary.
    Database link: Q9BQ51

  • Positive control

    • Human thyroid cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab200377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
  • Tissue specificity

    Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization

    Secreted; Cell membrane and Endomembrane system.
  • Information by UniProt
  • Database links

  • Alternative names

    • B7 dendritic cell molecule antibody
    • B7-DC antibody
    • B7DC antibody
    • bA574F11.2 antibody
    • Btdc antibody
    • Butyrophilin B7 DC antibody
    • Butyrophilin B7-DC antibody
    • Butyrophilin B7DC antibody
    • CD 273 antibody
    • CD273 antibody
    • CD273 antigen antibody
    • MGC142238 antibody
    • MGC142240 antibody
    • PD 1 ligand 2 antibody
    • PD L2 antibody
    • PD-1 ligand 2 antibody
    • PD-L2 antibody
    • PD1 ligand 2 antibody
    • PD1L2_HUMAN antibody
    • PDCD 1 ligand 2 antibody
    • PDCD1 ligand 2 antibody
    • PDCD1L2 antibody
    • Pdcd1lg2 antibody
    • PDL 2 antibody
    • PDL2 antibody
    • Programmed cell death 1 ligand 2 antibody
    • Programmed death ligand 2 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling PD-L2 with ab200377 at 1/40 dilution.

References

This product has been referenced in:

  • Zhang X  et al. Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma. BMC Cancer 19:360 (2019). Read more (PubMed: 30992011) »
  • Guo PD  et al. Clinicopathological analysis of PD-L2 expression in colorectal cancer. Onco Targets Ther 11:7635-7642 (2018). Read more (PubMed: 30464512) »
See all 2 Publications for this product

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