Key features and details
- Potent, highly specific Cdk4/Cdk6 inhibitor
- CAS Number: 571190-30-2
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Product namePD0332991, Cdk4/Cdk6 inhibitor
DescriptionPotent, highly specific Cdk4/Cdk6 inhibitor
Potent, highly specific inhibitor of Cdk4 (IC50 = 11 nM) and Cdk6 (IC50 = 16 nM). Displays selectivity for Cdk4/6 over a panel of 36 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines. Blocks growth of intracranial glioblastoma multiforme xenografts in mice. Blood-brain barrier permeable.
This product is manufactured by BioVision, an Abcam company and was previously called 2843 PD0332991. 2843-25 is the same size as the 25 mg size of ab218118.
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab218118 has not yet been referenced specifically in any publications.