PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist (ab144564)

Overview

  • Product name

    PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist
  • Description

    Potent, selective, non-peptide angiotensin AT2 receptor antagonist
  • Biological description

    Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
  • Purity

    > 98%
  • CAS Number

    136676-91-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate)
  • Molecular weight

    736.66
  • Molecular formula

    C31H32N4O3.2CF3CO2H
  • PubChem identifier

    6604951
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.CN(C)c1ccc(cc1C)Cn2cnc3CN([C@@H](Cc23)C(=O)O)C(=O)C(c4ccccc4)c5ccccc5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Park MH  et al. Angiotensin II potentiates zinc-induced cortical neuronal death by acting on angiotensin II type 2 receptor. Mol Brain 6:50 (2013). Read more (PubMed: 24289788) »
  • Liu SS  et al. Hypoxia-induced collagen synthesis of human lung fibroblasts by activating the angiotensin system. Int J Mol Sci 14:24029-45 (2013). Read more (PubMed: 24336063) »
  • Blankley CJ  et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem 34:3248-60 (1991). Read more (PubMed: 1956044) »
See 1 Publication for this product

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