Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Several tissues, including brain, kidney, testes and heart.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Li L et al. Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol302:H2112-21 (2012).
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