Overview

  • Product name

  • Description

    Rabbit polyclonal to PDE2A
  • Host species

    Rabbit
  • Specificity

    This antibody has no cross reactivity against PDE2B or with other PDE family members tested so far.
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    EVPDLDGTRAPVNG CCSL

    , corresponding to C terminal amino acids 897-914 of Mouse PDE2A

  • Positive control

    • Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab14604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notes
    IP: 1/250.
    WB: 1/500. Detects a band of approximately 95-97 kDa in samples from rat brain.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
    • Tissue specificity

      Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
    • Sequence similarities

      Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
      Contains 2 GAF domains.
    • Domain

      GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • 5''-cyclic phosphodiesterase antibody
      • cGMP dependent 3'5' cyclic phosphodiesterase antibody
      • cGMP stimulated phosphodiesterase 1 antibody
      • cGMP stimulated phosphodiesterase 4 antibody
      • cGMP-dependent 3'' antibody
      • cGMP-stimulated phosphodiesterase 2 antibody
      • CGS PDE antibody
      • CGS-PDE antibody
      • cGSPDE antibody
      • Cyclic GMP stimulated phosphodiesterase antibody
      • Cyclic GMP-stimulated phosphodiesterase antibody
      • Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase antibody
      • PDE 2A antibody
      • PDE 2A1 antibody
      • PDE 2A4 antibody
      • PDE2A antibody
      • PDE2A_HUMAN antibody
      • PDE2A1 antibody
      • PDE2A4 antibody
      • phosphodiesterase 2A antibody
      • Phosphodiesterase 2A cGMP stimulated antibody
      see all

    References

    This product has been referenced in:

    • Kallenborn-Gerhardt W  et al. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology 121:372-82 (2014). Read more (PubMed: 24758774) »
    See 1 Publication for this product

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