Overview

  • Product name

  • Description

    Goat polyclonal to PDE3B
  • Host species

    Goat
  • Specificity

    Does not cross react with PDE4A variants nor with any other PDEs.
  • Tested applications

    Suitable for: IP, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (Human) (selective for only PDE3B variant).

Properties

Applications

Our Abpromise guarantee covers the use of ab42091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/200.
WB 1/500. Detects a band of approximately 145 kDa (predicted molecular weight: 145 kDa).

Target

  • Function

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism.
  • Tissue specificity

    Abundant in adipose tissues.
  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5''-cyclic phosphodiesterase B antibody
    • Adipocyte cAMP phosphodiesterase cGMP inhibited antibody
    • AI847709 antibody
    • cAMP Phosphodiesterase, adipocyte, cGMP-inhibited antibody
    • CGI-PDE B antibody
    • CGIP1 antibody
    • CGIPDE B antibody
    • CGIPDE1 antibody
    • cGMP inhibited 3 5 cyclic phosphodiesterase B antibody
    • CGMP inhibited cAMP phophodiesterase antibody
    • cGMP-inhibited 3'' antibody
    • Cyclic GMP inhibited phosphodiesterase B antibody
    • Cyclic GMP-inhibited phosphodiesterase B antibody
    • Cyclic nucleotide phosphodiesterase antibody
    • HcGIP1 antibody
    • HcGIP1, rat, homolog of antibody
    • Pde3b antibody
    • PDE3B_HUMAN antibody
    • Phosphodiesterase 3B antibody
    • Phosphodiesterase 3B cGMP inhibited antibody
    see all

Images

  • Anti-PDE3B antibody (ab42091) at 1/250 dilution + PDE3B protein

    Predicted band size: 145 kDa
    Observed band size: 145 kDa

References

This product has been referenced in:

  • Yin C  et al. PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation. PLoS One 14:e0214606 (2019). Read more (PubMed: 30990811) »
  • Guo CH  et al. Effects of Chinese Medicinal Formula BNG-1 on Phosphodiesterase 3B Expression, Hepatic Steatosis, and Insulin Resistance in High Fat Diet-induced NAFLD Mice. Int J Med Sci 15:1194-1202 (2018). Read more (PubMed: 30123057) »
See all 2 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Question
Answer

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. I have contacted the lab to see if they have any insight as to why this wasn't working to detect the mouse protein. As requested, I have issued a free of charge replacement of ab95814.  This item is currently backordered, but to check the status of the order please contact our Customer Service team and reference this number. Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know. I wish you the best of luck with your research.  

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Answer

Thank you for your enquiry. I can confirm that these antibodies do not cross react to each other proteins. I hope this information will be helpful. If there is anything else that I can help you with, please do not hesitate to contact me.

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