Overview

  • Product name
    Anti-PDE4D antibody [EPR11823-31]
    See all PDE4D primary antibodies
  • Description
    Rabbit monoclonal [EPR11823-31] to PDE4D
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human PDE4D aa 650 to the C-terminus. The exact sequence is proprietary.
    Database link: Q08499

  • Positive control
    • Human fetal heart and fetal brain lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab171750 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 91 kDa.
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function
      Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
    • Tissue specificity
      Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
    • Pathway
      Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
    • Involvement in disease
      Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.
    • Sequence similarities
      Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
    • Post-translational
      modifications
      Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
    • Cellular localization
      Cytoplasm. Membrane. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • cAMP specific 3',5' cyclic phosphodiesterase 4D antibody
      • DKFZp686M11213 antibody
      • 5''-cyclic phosphodiesterase 4D antibody
      • cAMP specific phosphodiesterase 4D antibody
      • cAMP specific phosphodiesterase PDE4D6 antibody
      • cAMP-specific 3'' antibody
      • DPDE3 antibody
      • Dunce like phosphodiesterase E3 antibody
      • FLJ97311 antibody
      • HSPDE4D antibody
      • PDE43 antibody
      • Pde4d antibody
      • PDE4D_HUMAN antibody
      • PDE4DN2 antibody
      • Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody
      • Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody
      • Phosphodiesterase 4D cAMP specific antibody
      • Phosphodiesterase 4D, cAMP specific (dunce) antibody
      • STRK1 antibody
      see all

    Images

    • All lanes : Anti-PDE4D antibody [EPR11823-31] (ab171750) at 1/1000 dilution

      Lane 1 : Human fetal heart lysate
      Lane 2 : Human fetal brain lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 91 kDa

    References

    ab171750 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab171750.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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