Anti-PDE6 alpha antibody (ab5660)
- Datasheet
- References (1)
- Protocols
Overview
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Product name
Anti-PDE6 alpha antibody
See all PDE6 alpha primary antibodies -
Description
Rabbit polyclonal to PDE6 alpha -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Sheep, Cow
Predicted to work with: Mouse, Chicken, Human
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Immunogen
Synthetic peptide corresponding to Human PDE6C aa 16-29.
Sequence:MPQFAKEYFDRKLR
(Peptide available asab5863) -
Positive control
- WB: sheep retinal extract.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading... -
Purity
Ammonium Sulphate Precipitation -
Purification notes
Concentration: not determined. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab5660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500. Detects a band of approximately 90 kDa. |
Target
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Function
This protein participates in processes of transmission and amplification of the visual signal. -
Involvement in disease
Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 281973 Cow
- Entrez Gene: 5145 Human
- Entrez Gene: 225600 Mouse
- Omim: 180071 Human
- SwissProt: P11541 Cow
- SwissProt: P16499 Human
- SwissProt: P27664 Mouse
- Unigene: 151710 Human
see all -
Alternative names
- 5''-cyclic phosphodiesterase subunit alpha antibody
- CGPR A antibody
- GMP PDE alpha antibody
see all
Images
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Western blot - Anti-PDE6 alpha antibody (ab5660)Western blot of PDE6C on sheep retinal extracts using ab5660.
Protocols
Datasheets and documents
References
This product has been referenced in:
- Iribarne M et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . Read more (PubMed: 28378769) »
