Anti-PDE6 alpha antibody (ab5660)

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Western blot - Anti-PDE6 alpha antibody (ab5660)

    Key features and details

    • Rabbit polyclonal to PDE6 alpha
    • Suitable for: WB
    • Reacts with: Sheep
    • Isotype: IgG

    Overview

    • Product name

      Anti-PDE6 alpha antibody
      See all PDE6 alpha primary antibodies

    • Description

      Rabbit polyclonal to PDE6 alpha

    • Host species

      Rabbit

    • Tested Applications & Species

      Application Species
      WB
      Sheep
      See all applications and species data

    • Immunogen

      Synthetic peptide corresponding to Human PDE6C aa 16-29.
      Sequence:

      MPQFAKEYFDRKLR


      (Peptide available as ab5863)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • Positive control

      • WB: sheep retinal extract.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab5660 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Sheep
    All applications
    Mouse
    Chicken
    Human
    Application Abreviews Notes
    WB
    1/500. Detects a band of approximately 90 kDa.
    Notes
    WB
    1/500. Detects a band of approximately 90 kDa.

    Target

    • Function

      This protein participates in processes of transmission and amplification of the visual signal.

    • Involvement in disease

      Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

    • Sequence similarities

      Belongs to the cyclic nucleotide phosphodiesterase family.
      Contains 2 GAF domains.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      see all

    • Alternative names

      • 5''-cyclic phosphodiesterase subunit alpha antibody
      • CGPR A antibody
      • GMP PDE alpha antibody
      • GMP-PDE alpha antibody
      • PDE 6 alpha antibody
      • PDE 6A antibody
      • PDE V B1 antibody
      • PDE V-B1 antibody
      • PDE6A antibody
      • PDE6A_HUMAN antibody
      • PDEA antibody
      • Phosphodiesterase 6 alpha antibody
      • Phosphodiesterase 6A alpha subunit antibody
      • Phosphodiesterase 6A antibody
      • Phosphodiesterase 6A cGMP specific rod alpha antibody
      • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody
      • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody
      • Rod cGMP-specific 3'' antibody
      see all

    Images

    • Western blot - Anti-PDE6 alpha antibody (ab5660)
      Western blot - Anti-PDE6 alpha antibody (ab5660)

      Western blot of PDE6C on sheep retinal extracts using ab5660.

    References (1)

    Publishing research using ab5660? Please let us know so that we can cite the reference in this datasheet.

    ab5660 has been referenced in 1 publication.

    • Iribarne M  et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . PubMed: 28378769

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