Anti-PDE6 alpha antibody (ab5660)
- Datasheet
- References (1)
- Protocols
Overview
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Product nameAnti-PDE6 alpha antibody
See all PDE6 alpha primary antibodies -
DescriptionRabbit polyclonal to PDE6 alpha
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Host speciesRabbit
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Sheep, Cow
Predicted to work with: Mouse, Chicken, Human
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Immunogen
Synthetic peptide corresponding to Human PDE6C aa 16-29.
Sequence:MPQFAKEYFDRKLR
(Peptide available asab5863) -
Positive control
- WB: sheep retinal extract.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Storage bufferPreservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading... -
PurityAmmonium Sulphate Precipitation
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Purification notesConcentration: not determined.
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab5660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500. Detects a band of approximately 90 kDa.Can be blocked with PDE6C peptide (ab5863). |
Target
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FunctionThis protein participates in processes of transmission and amplification of the visual signal.
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Involvement in diseaseDefects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains. -
Cellular localizationCell membrane.
- Information by UniProt
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Database links
- Entrez Gene: 281973 Cow
- Entrez Gene: 5145 Human
- Entrez Gene: 225600 Mouse
- Omim: 180071 Human
- SwissProt: P11541 Cow
- SwissProt: P16499 Human
- SwissProt: P27664 Mouse
- Unigene: 151710 Human
see all -
Alternative names
- 5''-cyclic phosphodiesterase subunit alpha antibody
- CGPR A antibody
- GMP PDE alpha antibody
see all
Images
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Western blot - Anti-PDE6 alpha antibody (ab5660)Western blot of PDE6C on sheep retinal extracts using ab5660.
Protocols
Datasheets and documents
References
This product has been referenced in:
- Iribarne M et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . Read more (PubMed: 28378769) »
