Anti-PDE6 alpha antibody (ab5660)
Key features and details
- Rabbit polyclonal to PDE6 alpha
- Suitable for: WB
- Reacts with: Sheep
- Isotype: IgG
Overview
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Product name
Anti-PDE6 alpha antibody
See all PDE6 alpha primary antibodies -
Description
Rabbit polyclonal to PDE6 alpha -
Host species
Rabbit -
Tested Applications & Species
Application Species WB Sheep -
Immunogen
Synthetic peptide corresponding to Human PDE6C aa 16-29.
Sequence:MPQFAKEYFDRKLR
(Peptide available asab5863) -
Positive control
- WB: sheep retinal extract.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading...
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Purity
Ammonium Sulphate Precipitation -
Purification notes
Concentration: not determined. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab5660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Application | Species |
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WB |
Sheep
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All applications |
Mouse
Chicken
Human
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Application | Abreviews | Notes |
---|---|---|
WB |
1/500. Detects a band of approximately 90 kDa.
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Notes |
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WB
1/500. Detects a band of approximately 90 kDa. |
Target
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Function
This protein participates in processes of transmission and amplification of the visual signal. -
Involvement in disease
Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 5145 Human
- Entrez Gene: 225600 Mouse
- Omim: 180071 Human
- SwissProt: P16499 Human
- SwissProt: P27664 Mouse
- Unigene: 151710 Human
- Unigene: 567314 Human
- Unigene: 1370 Mouse
see all -
Alternative names
- 5''-cyclic phosphodiesterase subunit alpha antibody
- CGPR A antibody
- GMP PDE alpha antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab5660 has been referenced in 1 publication.
- Iribarne M et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . PubMed: 28378769