Key features and details
- Rabbit polyclonal to PDE6C
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PDE6C antibody
See all PDE6C primary antibodies
DescriptionRabbit polyclonal to PDE6C
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide within Human PDE6C (N terminal). The exact sequence is proprietary.
Database link: P51160
- A172 cell lysate
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198744 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 99 kDa.|
Involvement in diseaseDefects in PDE6C are the cause of cone dystrophy type 4 (COD4) [MIM:613093]. An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains.
Cellular localizationCell membrane.
- Information by UniProt
- 5''-cyclic phosphodiesterase subunit alpha'' antibody
- cGMP phosphodiesterase 6C antibody
- COD4 antibody
ab198744 has been referenced in 1 publication.
- Thorn RJ et al. The loss and recovery of vertebrate vision examined in microplates. PLoS One 12:e0183414 (2017). PubMed: 28817700