Overview

  • Product name

  • Description

    Rabbit polyclonal to PDE6C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human PDE6C (N terminal). The exact sequence is proprietary.
    Database link: P51160

  • Positive control

    • A172 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab198744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 99 kDa.

Target

  • Involvement in disease

    Defects in PDE6C are the cause of cone dystrophy type 4 (COD4) [MIM:613093]. An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5''-cyclic phosphodiesterase subunit alpha'' antibody
    • cGMP phosphodiesterase 6C antibody
    • COD4 antibody
    • Cone cGMP specific 3' 5' cyclic phosphodiesterase subunit alpha' antibody
    • Cone cGMP-specific 3'' antibody
    • PDE 6C antibody
    • PDE6 alpha prime antibody
    • PDE6 alpha' antibody
    • PDE6C antibody
    • PDE6C_HUMAN antibody
    • PDEA2 antibody
    • Phosphodiesterase 6C cGMP specific cone alpha prime antibody
    see all

Images

  • Anti-PDE6C antibody (ab198744) at 1/1400 dilution + A172 cell lysate at 40 µg

    Predicted band size: 99 kDa


    Exposure time: 10 seconds

References

This product has been referenced in:

See 1 Publication for this product

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