• Product name

    Anti-PDE7A/HCP1 antibody [EPR7731]
    See all PDE7A/HCP1 primary antibodies
  • Description

    Rabbit monoclonal [EPR7731] to PDE7A/HCP1
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human PDE7A/HCP1.
    Database link: Q13946

  • Positive control

    • HuT78 cell lysate; Human skeletal muscle tissue; HuT78 cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     This product was previously labelled as PDE7A


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab154857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 56 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC/IF 1/250 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt or IP.
  • Target

    • Function

      Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
    • Tissue specificity

      PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
    • Pathway

      Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
    • Sequence similarities

      Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
    • Developmental stage

      Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.
    • Domain

      Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
    • Cellular localization

      Cytoplasm > cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions and Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions.
    • Information by UniProt
    • Database links

    • Alternative names

      • 5''-cyclic phosphodiesterase 7A antibody
      • HCP 1 antibody
      • HCP1 antibody
      • High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A antibody
      • High affinity cAMP-specific 3'' antibody
      • P2A antibody
      • PDE 7 antibody
      • PDE 7A antibody
      • PDE1/PDE2 yeast human complement of antibody
      • PDE7 antibody
      • PDE71 antibody
      • PDE7A antibody
      • PDE7A_HUMAN antibody
      • Phosphodiesterase 7A antibody
      • Phosphodiesterase isozyme 7 antibody
      • Phosphodiesterase7A antibody
      • Rolipram insensitive phosphodiesterase type 7 antibody
      • TM 22 antibody
      • TM22 antibody
      see all


    • Anti-PDE7A/HCP1 antibody [EPR7731] (ab154857) at 1/1000 dilution + HuT78 cell lysate at 10 µg

      Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 56 kDa

    • Immunohistochemical analysis of paraffin-embedded Human skeletal muscle tissue labeling PDE7A/HCP1 with ab154857 at 1/100 dilution.

    • Immunofluorescent analysis of HuT78 cells labeling PDE7A/HCP1 with ab154857 at 1/250 dilution.


    This product has been referenced in:

    See 1 Publication for this product

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