Key features and details
- Rabbit polyclonal to PDE8A
- Suitable for: WB, IP
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-PDE8A antibody
See all PDE8A primary antibodies
DescriptionRabbit polyclonal to PDE8A
Tested applicationsSuitable for: WB, IPmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic cyclic peptide, corresponding to the mid region of PDE8A.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab14619 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500. Detects a band of approximately 98-102 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Tissue specificityExpressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
PathwayPurine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Sequence similaritiesBelongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
DomainComposed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
- Information by UniProt
- 5''-cyclic phosphodiesterase 8A antibody
- cAMP specific cyclic nucleotide phosphodiesterase 8A antibody
- FLJ16150 antibody
ab14619 has been referenced in 1 publication.
- Kelly MP et al. Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. Cell Signal 26:383-397 (2013). Mouse, Rat . PubMed: 24184653