PDE8A peptide (ab65448)

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Key features and details

  • Suitable for: Blocking

Description

Specifications

Our Abpromise guarantee covers the use of ab65448 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names

    • 5''-cyclic phosphodiesterase 8A
    • cAMP specific cyclic nucleotide phosphodiesterase 8A
    • FLJ16150
    • High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A
    • High affinity cAMP-specific and IBMX-insensitive 3''
    • HsT19550
    • PDE 8A
    • PDE8A
    • PDE8A_HUMAN
    • Phosphodiesterase 8A
    • Phosphodiesterase8A
    • Weakly similar to 3'5' cyclic nucleotide phosphodiesterase
    see all

  • Function

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

  • Tissue specificity

    Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

  • Pathway

    Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.

  • Domain

    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab65448? Please let us know so that we can cite the reference in this datasheet.

ab65448 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

estoy interesado en la enzima PDE8A peptide y veo que hay 3 referencias de las cuales desconozco la diferencia entre las referencias ab65448 y la ab65452.

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Answer

ab65448 corresponde a una secuencia de aminoácidos alrededor de la zona N terminal de la proteína. Sin embargo, ab65452 pertenece a una secuencia en torno a la zona C terminal de la proteína.

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