Overview

  • Product name

  • Description

    Rabbit polyclonal to PDE8B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human PDE8B (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control

    • Human Thyroid tissue.
  • General notes

    For short term storage: at -4°C

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.7
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab61817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
  • Tissue specificity

    Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.
  • Pathway

    Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • Involvement in disease

    Defects in PDE8B are the cause of striatal degeneration autosomal dominant (ADSD) [MIM:609161]. It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present.
  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • Domain

    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3' 5' cyclic nucleotide phosphodiesterase 8B antibody
    • 3'5' cyclic nucleotide phosphodiesterase 8B antibody
    • Cell proliferation-inducing gene 22 protein antibody
    • FLJ11212 antibody
    • High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B antibody
    • High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8B antibody
    • High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody
    • HSPDE 8B antibody
    • HsPDE8B antibody
    • PDE 8B antibody
    • PDE8B antibody
    • PDE8B_HUMAN antibody
    • Phosphodiesterase 8B antibody
    • Phosphodiesterase8B antibody
    • PIG22 antibody
    see all

Images

  • Immunohistochemistry analysis of human Thyroid tissue (Formalin-Fixed Paraffin-Embedded) using ab61817 at 5µg/ml. Detection was done with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin, and chromogen.

References

ab61817 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

Thank you for your enquiry. I sincerely apologize that the IHC-P image does not contain sufficient information. The staining was actually performed with a biotinylated goat anti-rabbit IgG secondary antibody, with alkaline phosphatase-streptavidin and chromogen detection. Therefore, the positive staining is the one in blue color, cytoplasmic/membraneous staining of grandular cells. I hope this information will be helpful. If there is anything else that I can help you with please do not hesitate to contact me. Have a nice day!

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